Table 4 Cox multivariable models for time to progression and overall survival ^a

Regimen (GD vs. D)

0.60

(0.42-

0.84)

0.003

0.88

(0.67-

1.15)

0.34

TIMP-1 (positive vs. negative)

0.82

(0.55-

1.21)

0.31

0.71

(0.52-

0.98)

0.03

PAM50

0.007

0.0001

  Luminal A

78

0.68

(0.45-

1.04)

0.08

0.78

0.56

1.08

0.14

  Luminal B

100^b

1.00

referent

1.00

referent

  Basal-like

40

1.75

(1.05-

2.92)

0.03

2.39

(1.56-

3.64)

<0.0001

  HER2-enriched

46

1.30

(0.82-

2.07)

0.27

1.25

(0.85-

1.84)

0.25

Visceral disease (yes vs. no)

1.60

(1.07-

2.39)

0.02

1.13

(0.84-

1.53)

0.42

Stage of disease (locally advanced vs. metastatic)

1.96

(1.02-

3.76)

0.04

0.72

(0.42-

1.24)

0.23

Metastatic sites (3+ vs. 1-2)

1.24

(0.86-

1.77)

0.25

1.52

(1.13-

2.04)

0.01

ECOG performance status (2 vs. 0-1)

1.19

(0.85-

1.67)

0.31

1.47

(1.12-

1.93)

0.006