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Table 1 Demographic features found in the general population (control cohort) and in the colorectal cancer cohort

From: Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls

General population, AAT-Pi* genotypes

Colorectal cancer, AAT-Pi* genotypes

P

 

Total

MM

MS

MZ

SS

SZ

Total

MM

MS

MZ

SS

SZ

 

Genotypes, n (%)

327 (100)

256 (78.3)

60 (18.3)

9 (0.03)

1 (.003)

1 (.003)

267 (100)

207 (77.5)

49 (18.4)

10 (0.04)

0 (0)

1 (0.004)

0.985

Males, n (%)

219 (67)

171 (67)

40 (67)

7 (78)

0 (0)

1 (100)

169 (63)

131 (63)

32 (65)

6 (60)

-

-

0.712

Age, years [SD]

70.0 [7.5]

69.8 [7.4]

70.5 [7.9]

73.2 [6.4]

65.0 -

80.0 -

72 [9.6]

72.5 [9.8]

72.8 [9.2]

70.2 [8.1]

-

81 [NA]

0.713

Familial CRC, n (%)

13 (3.9)

12 (5)

1 (1.7)

0 (0)

0 (0)

0 (0)

11 (4)

10 (5)

1 (2)

0 (0)

-

0 (0)

0.590

Alcohol abuse, n (%)*

66 (20)

60 (23)

5 (8)

1 (11)

0 (0)

0 (0)

34 (13)

27 (13)

5 (10)

2 (20)

-

0 (0)

0.706

TOB n (%)**

88 (27)

77 (30)

8 (13)

2 (22)

0 (0)

1 (100)

103 (39)

84 (41)

16 (33)

3 (30)

-

0 (0)

0.640

NSAIDS n (%)

4 (1)

3 (1)

0 (0)

1 (11)

0 (0)

0 (0)

34 (12)

25 (12)

9 (18)

0 (0)

-

0 (0)

0.345

OW, n (%)***

10 (3)

8 (3)

1 (2)

1 (11)

0 (0)

0 (0)

19 (7)

17 (8)

1 (2)

1 (10)

-

0 (0)

0.384

CWPC, n (%)

2 (1)

0 (0)

0 (0)

1 (11)

0 (0)

1 (100)

25 (9)

22 (10)

2 (4)

1 (10)

-

0 (0)

0.421

ATH, n (%)

124 (38)

113 (44)

10 (17)

1 (11)

0 (0)

0 (0)

112 (42)

90 (44)

18 (37)

4 (40)

-

0 (0)

0.799

DL, n (%)

40 (12)

36 (14)

4 (7)

0 (0)

0 (0)

0 (0)

56 (21)

43 (21)

9 (18)

3 (30)

-

1 (100)

0.491

DM n (%)

18 (5)

17 (7)

1 (2)

0 (0)

0 (0)

0 (0)

50 (19)

42 (20)

6 (12)

2 (20)

-

0 (0)

0.519

CLD, n (%)****

0 (0)

-

-

-

-

-

17 (6)

13 (6)

3 (6)

1 (10)

-

0 (0)

1.000

  1. Pi* protease inhibitor. AAT alpha-1 antitrypsin, n number. * > 40 g ethanol consumed/day. **Current smokers or ex-smokers of >15 packs/year. OW overweight, ***BMI 30 kg/m2. CLD chronic liver disease, ****Mostly, chronic hepatitis and/or liver cirrhosis. CWPC coal workers’ pneumoconiosis. DM diabetes mellitus. ATH arterial hypertension. NSAIDS chronic intake of non-steroidal anti-inflammatory drugs. TOB tobacco abuse. DL Dyslipidemia. No significant differences were found in any of the parameters.