Figure 1

Pedigree of the BRCA1 + family used in the study. Eight members of this family were sequenced by exome sequencing, of which #1 (62y), #2 (53y), #4 (35y), #5 (35y), #6 (36y), #7 (35y) are breast cancer-affected and #3 (65y) and #8 (45y) are breast cancer-unaffected members. All six affected members are BRCA1+ whereas the two unaffected members are not. #9 and #10 were used in validation to remove the variants transmitted from them to their daughters.