Table 5 Univariate associations of clinical and pathologic features with recurrence for 265 patients with stage III colon cancer
From: Predictors of recurrence free survival for patients with stage II and III colon cancer
Patient and tumor characteristics | Hazard ratio (95% CI) | P-value |
|---|---|---|
Year of surgery (1-year increase) | 0.98 (0.86 – 1.11) | 0.71 |
Age at surgery (10-year increase) | 1.10 (0.91 – 1.33) | 0.31 |
Sex | ||
Female | 1.0 (reference) | |
Male | 1.16 (0.75 – 1.80) | 0.51 |
Adjuvant chemotherapy | ||
No | 1.0 (reference) | |
Yes | 0.68 (0.42 – 1.09) | 0.11 |
Tumor location† | ||
Right | 1.0 (reference) | |
Sigmoid | 0.82 (0.49 – 1.38) | 0.46 |
Transverse | 1.01 (0.50 – 2.03) | 0.98 |
Left | 0.78 (0.35 – 1.75) | 0.55 |
Tumor location† | ||
Right, transverse, or left | 1.0 (reference) | |
Sigmoid | 0.85 (0.52 – 1.39) | 0.51 |
Primary tumor size (20-mm increase)† | 1.16 (0.96 – 1.41) | 0.12 |
Primary tumor classification | ||
T1 | 1.0 (reference) | |
T2 | 3.70 (0.46 – 30.05) | 0.22 |
T3 | 4.34 (0.60 – 31.34) | 0.15 |
T4 | 9.59 (1.23 – 74.94) | 0.031 |
Primary tumor classification† | ||
T1, T2, or T3 | 1.0 (reference) | |
T4 | 2.35 (1.21 – 4.57) | 0.012 |
Regional lymph node involvement | ||
N1 | 1.0 (reference) | |
N2 | 3.23 (2.06 – 5.06) | <0.001 |
Positive lymph nodes (1-node increase) | 1.23 (1.17 – 1.30) | <0.001 |
Negative lymph nodes (10-node increase) | 1.04 (0.78 – 1.37) | 0.80 |
Total lymph nodes (10-node increase) | 1.34 (1.06 – 1.69) | 0.013 |
Tumor differentiation† | ||
Well | 1.0 (reference) | |
Moderate | 1.50 (0.89 – 2.52) | 0.13 |
Poor | 1.90 (0.86 – 4.17) | 0.11 |
Tumor differentiation† | ||
Well or moderate | 1.0 (reference) | |
Poor | 1.45 (0.72 – 2.90) | 0.30 |
Lymphovascular invasion | ||
No | 1.0 (reference) | |
Yes | 2.37 (0.95 – 5.89) | 0.06 |
Perineural invasion | ||
No | 1.0 (reference) | |
Yes | 0.99 (0.14 – 7.14) | 0.99 |