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Figure 4 | BMC Cancer

Figure 4

From: YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells

Figure 4

YB-1 regulates the Sox2 transcription reporter activity only in the RR cell subset. (A) Luciferase assay results of Sox2 reporter luciferase activity in MCF7 Unsorted cells (with natural proportions of RU and RR cells) after 72-hour treatments of scrambled or 2 unique YB-1 siRNAs at 20 nM. (B) Luciferase assay data showing Sox2 reporter luciferase activity relative to the RU siRNA treatment luciferase value and (C) flow cytometry analyses of Sox2 reporter GFP expression in MCF7 and ZR751 RU and RR cells after 72-hour 20 nM scrambled or YB-1 siRNA treatments.

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BMC Cancer

ISSN: 1471-2407

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