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Table 4 Univariate and multivariate survival analysis for disease-specific and overall survival in OSCC (Cohort III)

From: Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma

 

Univariate analysis

 

Disease-specific survival

Overall survival

Variable

HR (95% CI)

p-value

C-index

HR (95% CI)

p-value

C-index

Age

1.02 (0.96-1.08)

0.58

0.56

1.05 (1.01-1.09)

0.02

0.67

Tumor site

-

0.24

0.67

0.92 (0.31-2.68)

0.87

0.53

Tumor size

31.59 (1.57-633.64)

0

0.66

15.93 (1.41-179.93)

0.02

0.58

Node status

-

0

0.84

2.96 (1.19-7.39)

0.02

0.64

Differentiation

-

0.11

0.73

0.95 (0.17-5.18)

0.11

0.63

Tumor inflammatory infiltration

3.91 (0.46-33.48)

0.20

0.67

0.91 (0.31-2.72)

0.99

0.51

p16

0.62 (0.074-5.16)

0.65

0.53

0.69 (0.20-2.36)

0.55

0.53

AZGP1 cytoplasmic

0.95 (0.18-4.87)

0.95

0.51

0.88 (0.33-2.32)

0.80

0.52

AZGP1 nuclear

4.57 (0.55-38.01)

0.12

0.65

0.86 (0.35-2.12)

0.75

0.52

BTG2

1.25 (0.28-5.58)

0.77

0.53

0.79 (0.30-2.07)

0.63

0.53

CBX2

-

0.15

0.61

1.12 (0.37-3.37)

0.84

0.51

CNTNAP2

5.70 (1.27-25.57)

0.01

0.66

1.34 (0.39-4.62)

0.65

0.52

NME5

0.37 (0.045-3.11)

0.34

0.58

0.58 (0.19-1.75)

0.33

0.56

S100A8

0.35 (0.043-2.95)

0.32

0.59

0.10 (0.014-0.76)

0.01

0.65

SCUBE2

-

0.090

0.65

1.25 (0.47-3.33)

0.65

0.53

SERPINA11

2.23 (0.50-9.99)

0.28

0.60

0.98 (0.39-2.50)

0.97

0.50

STC2

0.17 (0.023-1.71)

0.10

0.68

0.68 (0.27-1.69)

0.40

0.55

STK32B

0.31 (0.037-2.54)

0.25

0.61

0.47 (0.16-1.41)

0.17

0.58

SUSD3

1.60 (0.31-8.26)

0.57

0.55

0.54 (0.22-1.34)

0.18

0.58

UBE2C

2.56 (0.49-13.28)

0.25

0.57

2.49 (0.88-7.01)

0.074

0.57

WHSC1L1

0.86 (0.10-7.16)

0.89

0.51

1.18 (0.27-5.10)

0.83

0.51

 

Multivariate analysis

 

Disease- specific survival

Overall survival

 

HR (95% CI)

p- value

C-index

HR (95% CI)

p- value

C- index

CNTNAP2 †

3.56 (0.78-16.17)

0.10

0.95

-

-

-

S100A8 ‡

-

-

-

0.11 (0.013-0.92)

0.01

0.83

  1. Abbreviations: OSCC oral squamous cell carcinoma, HR hazard ratio, CI confidence interval, C-index concordance index.
  2. Statistically significant data (p < 0.05) indicated with bold text.
  3. † Adjusted for node status and tumor size.
  4. ‡ Adjusted for node status, tumor size, differentiation, and age.
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BMC Cancer

ISSN: 1471-2407

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