Variables | DFS | OS | ||||
---|---|---|---|---|---|---|
 | HR | 95% CI | Pvalue | HR | 95% CI | Pvalue |
Univariate analysis | Â | Â | Â | Â | . | Â |
Age (<50Â years vs. >50Â years) | 1.122 | 0.659-1.910 | 0.671 | 1.057 | 0.589-1.899 | 0.852 |
Gender (male vs. female) | 1.584 | 0.907-2.768 | 0.106 | 1.739 | 0.933-3.240 | 0.082 |
Location (Distal vs. Middle + Proximal) | 1.232 | 0.811-1.872 | 0.327 | 1.498 | 0.830-2.702 | 0.180 |
tumor size (>5Â cm vs. <5Â cm) | 1.493 | 0.876-2.543 | 0.141 | 1.260 | 0.938-1.692 | 0.124 |
Histologic differentiation (Well + Moderately vs. Poorly + Undifferentiated) | 0.743 | 0.428-1.288 | 0.289 | 0.798 | 0.436-1.458 | 0.463 |
Invasion depth (T1 + T2 vs.T3 + T4) | 0.629 | 0.370-1.069 | 0.087 | 0.724 | 0.403-1.300 | 0.279 |
TNM stage (I + II vs. III + IV) | 0.521 | 0.303-0.896 | 0.018** | 0.433 | 0.239-0.786 | 0.006** |
Lymphatic metastasis (No vs. Yes) | 0.838 | 0.642-1.093 | 0.192 | 0.899 | 0.671-1.204 | 0.474 |
Regional lymph nodes (PN0+ PN1vs. PN2+ PN3) | 0.584 | 0.332-1.024 | 0.061 | 0.575 | 0.310-1.065 | 0.078 |
Distant metastasis (No vs. Yes) | 0.456 | 0.264-0.787 | 0.005** | 0.432 | 0.231-0.811 | 0.009** |
Expression of GAS5 (High vs. Low) | 0.407 | 0.235-0.706 | 0.001** | 0.591 | 0.436-0.803 | 0.001** |
Multivariate analysis | Â | Â | Â | Â | Â | Â |
TNM stage (I + II vs. III + IV) | 0.631 | 0.357-1.115 | 0.113 | 0.537 | 0.289-1.000 | 0.049* |
Distant metastasis (No vs. Yes) | 0.384 | 0.123-1.197 | 0.099 | 0.381 | 0.105-1.389 | 0.144 |
Expression of GAS5 (High vs. Low) | 0.466 | 0.263-0.828 | 0.009** | 0.412 | 0.218-0.776 | 0.006** |