Figure 9
Effect of CYT387 on the proliferation of HEY cells and ascites-derived tumor cells. (A) HEY cells were treated with paclitaxel, CYT387 and combination of CYT387 and paclitaxel for three days. [3H]-thymidine was added and the cells were harvested as described in the Materials. The data is a representation of three independent experiments performed in triplicate. Significant variations between the groups are indicated by *P <0.05. (B) Ascites-derived tumor cells obtained from three independent patients were treated as described in Figure 9 A. [3H]-thymidine uptake assay was performed as described in the Materials. The data is a representation of three independent experiments performed in triplicate on three ascites samples. Significant variations between the groups are indicated by *P <0.05, ***P < 0.001.