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Table 2 Odds ratio (OR) and 95% confidence intervals (CI) for breast cancer by categories in circulating 25(OH)D 2 , 25(OH)D 3 , and 25(OH)D levels by race/ethnicity a

From: Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case–control study in the multiethnic cohort study

  White African-American Native Hawaiian Japanese Latino Test for heterogeneity b
(n = 294) (n = 212) (n = 136) (n = 508) (n = 264)
Variables and categories No. cases/controls OR 95% CI No. cases/controls OR 95% CI No. cases/controls OR 95% CI No. cases/controls OR 95% CI No. cases/controls OR 95% CI Overall Whites vs. others
25(OH)D 2                       
 0 ng/mL 80/90 1.00    85/66 1.00    49/43 1.00    124/139 1.00    84/83 1.00     
 > 0 ng/mL 67/57 1.29 0.75 2.23 21/40 0.29 0.12 0.70 19/25 0.46 0.16 1.34 130/115 1.32 0.90 1.93 48/49 0.85 0.46 1.56 P = 0.817 P = 0.124
25(OH)D 3                       
 10 ng/mL increase 147/147 0.53 0.37 0.75 106/106 1.27 0.91 1.76 118/118 0.89 0.59 1.34 229/229 0.92 0.75 1.12 232/232 1.29 0.87 1.89 P = 0.059 P = 0.007
 20 ng/mL increase 147/147 0.28 0.14 0.56 106/106 1.61 0.83 3.11 118/118 0.80 0.35 1.79 229/229 0.84 0.57 1.24 232/232 1.65 0.76 3.57   
25(OH)D                       
 10 ng/mL increase 147/147 0.66 0.48 0.90 106/106 1.08 0.79 1.47 118/118 0.79 0.52 1.20 229/229 1.04 0.84 1.28 232/232 1.17 0.84 1.64 P = 0.086 P = 0.051
 20 ng/mL increase 147/147 0.43 0.23 0.80 106/106 1.16 0.63 2.16 118/118 0.63 0.27 1.45 229/229 1.08 0.71 1.65 232/232 1.38 0.71 2.69   
Vitamin D deficiency                       
Cutoff at 16 ng/mL                       
  ≥16 ng/mL 144/146 1.00    79/85 1.00    65/64 1.00    246/245 1.00    119/119 1.00     
  <16 ng/mL 3/1 4.98 0.40 62.1 27/21 1.36 0.59 3.13 3/4 1.44 0.18 11.5 8/9 0.72 0.24 2.14 13/13 1.01 0.31 3.29 P = 0.395 P = 0.465
Cutoff at 20 ng/mL                       
  ≥20 ng/mL 136/145 1.00    72/70 1.00    64/61 1.00    233/231 1.00    105/102 1.00     
  <20 ng/mL 11/2 7.50 1.41 39.8 34/36 0.74 0.36 1.53 4/7 0.74 0.13 4.29 21/23 0.96 0.47 1.97 27/30 0.90 0.41 1.95 P = 0.226 P = 0.023
Cutoff at 30 ng/mL                       
  ≥30 ng/mL 98/115 1.00    29/39 1.00    44/39 1.00    152/144 1.00    45/42 1.00     
  <30 ng/mL 49/32 2.56 1.27 5.14 77/67 1.34 0.64 2.79 24/29 0.64 0.28 1.49 102/110 0.86 0.58 1.29 87/90 0.76 0.40 1.46 P = 0.025 P = 0.026
  1. Abbreviation: 25(OH)D 2 25-hydroxyvitamin D2, 25(OH)D 3 25-hydroxyvitamin D3, 25(OH)D sum of 25(OH)D2 and 25(OH)D3.
  2. Note. Values are given in ng/mL. Multiply 2.5 to convert the values to nmol/L.
  3. aModeled through conditional logistic regression after adjustment for season, sunburn history, body mass index, strenuous sports, number of live births, family history of breast cancer, use of multivitamin, and use of calcium supplement.
  4. bTests based on the Wald statistic for cross-product terms between ethnicity and plasma vitamin D level.