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Table 2 Odds ratio (OR) and 95% confidence intervals (CI) for breast cancer by categories in circulating 25(OH)D 2 , 25(OH)D 3 , and 25(OH)D levels by race/ethnicity a

From: Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case–control study in the multiethnic cohort study

 

White

African-American

Native Hawaiian

Japanese

Latino

Test for heterogeneity b

(n = 294)

(n = 212)

(n = 136)

(n = 508)

(n = 264)

Variables and categories

No. cases/controls

OR

95% CI

No. cases/controls

OR

95% CI

No. cases/controls

OR

95% CI

No. cases/controls

OR

95% CI

No. cases/controls

OR

95% CI

Overall

Whites vs. others

25(OH)D 2

                      

 0 ng/mL

80/90

1.00

  

85/66

1.00

  

49/43

1.00

  

124/139

1.00

  

84/83

1.00

    

 > 0 ng/mL

67/57

1.29

0.75

2.23

21/40

0.29

0.12

0.70

19/25

0.46

0.16

1.34

130/115

1.32

0.90

1.93

48/49

0.85

0.46

1.56

P = 0.817

P = 0.124

25(OH)D 3

                      

 10 ng/mL increase

147/147

0.53

0.37

0.75

106/106

1.27

0.91

1.76

118/118

0.89

0.59

1.34

229/229

0.92

0.75

1.12

232/232

1.29

0.87

1.89

P = 0.059

P = 0.007

 20 ng/mL increase

147/147

0.28

0.14

0.56

106/106

1.61

0.83

3.11

118/118

0.80

0.35

1.79

229/229

0.84

0.57

1.24

232/232

1.65

0.76

3.57

  

25(OH)D

                      

 10 ng/mL increase

147/147

0.66

0.48

0.90

106/106

1.08

0.79

1.47

118/118

0.79

0.52

1.20

229/229

1.04

0.84

1.28

232/232

1.17

0.84

1.64

P = 0.086

P = 0.051

 20 ng/mL increase

147/147

0.43

0.23

0.80

106/106

1.16

0.63

2.16

118/118

0.63

0.27

1.45

229/229

1.08

0.71

1.65

232/232

1.38

0.71

2.69

  

Vitamin D deficiency

                      

Cutoff at 16 ng/mL

                      

  ≥16 ng/mL

144/146

1.00

  

79/85

1.00

  

65/64

1.00

  

246/245

1.00

  

119/119

1.00

    

  <16 ng/mL

3/1

4.98

0.40

62.1

27/21

1.36

0.59

3.13

3/4

1.44

0.18

11.5

8/9

0.72

0.24

2.14

13/13

1.01

0.31

3.29

P = 0.395

P = 0.465

Cutoff at 20 ng/mL

                      

  ≥20 ng/mL

136/145

1.00

  

72/70

1.00

  

64/61

1.00

  

233/231

1.00

  

105/102

1.00

    

  <20 ng/mL

11/2

7.50

1.41

39.8

34/36

0.74

0.36

1.53

4/7

0.74

0.13

4.29

21/23

0.96

0.47

1.97

27/30

0.90

0.41

1.95

P = 0.226

P = 0.023

Cutoff at 30 ng/mL

                      

  ≥30 ng/mL

98/115

1.00

  

29/39

1.00

  

44/39

1.00

  

152/144

1.00

  

45/42

1.00

    

  <30 ng/mL

49/32

2.56

1.27

5.14

77/67

1.34

0.64

2.79

24/29

0.64

0.28

1.49

102/110

0.86

0.58

1.29

87/90

0.76

0.40

1.46

P = 0.025

P = 0.026

  1. Abbreviation: 25(OH)D 2 25-hydroxyvitamin D2, 25(OH)D 3 25-hydroxyvitamin D3, 25(OH)D sum of 25(OH)D2 and 25(OH)D3.
  2. Note. Values are given in ng/mL. Multiply 2.5 to convert the values to nmol/L.
  3. aModeled through conditional logistic regression after adjustment for season, sunburn history, body mass index, strenuous sports, number of live births, family history of breast cancer, use of multivitamin, and use of calcium supplement.
  4. bTests based on the Wald statistic for cross-product terms between ethnicity and plasma vitamin D level.
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BMC Cancer

ISSN: 1471-2407

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