Table 2 Down-regulated genes in HPMCs exposed to malignant ascites versus to benign fluids (Fold change > 2, P < 0.05)
From: Role of malignant ascites on human mesothelial cells and their gene expression profiles
Unigene | Symbol | Description | Functions | Fold change |
|---|---|---|---|---|
Hs.602085 | PHLDA1 | Pleckstrin homology-like domain, member 1 | Nuclear protein | -3.40 |
Hs.624 | IL-8 | Interleukin 8 | Angiogenesis | -3.38 |
Hs.98367 | SOX17 | SRY-box 17 | Transcription | -3.33 |
Hs.345139 | GEM | GTP binding protein overexpressed in skeletal muscle | Intracellular signaling | -2.58 |
Hs.73853 | BMP2 | Bone morphogenetic protein 2 | Cell proliferation | -2.58 |
Hs.251526 | CCL7 | Chemokine ligand 7 | Inflammatory response | -2.54 |
Hs.591159 | PTHLH | Parathyroide hormone-like hormone | Ion binding | -2.44 |
Hs.643357 | ADAMTS1 | A disintegrin and metallopeptidase with thrombospondin type 1 | Cell proliferation | -2.34 |
Hs.517310 | RIPK4 | Receptor-interacting serine-threonine kinase 4 | Intracellular signaling | -2.32 |
Hs.616962 | GDF15 | Growth differentiation factor 15 | Intracellular signaling | -2.31 |
Hs.279522 | NR4A3 | Nuclear receptor subfamily 4, group A, member 3 | Transcription | -2.30 |
Hs.25829 | RASD1 | RAS, dexamethasone-induced 1 | Intracellular signaling | -2.27 |
Hs.516826 | TRIB3 | Tribbles homolog 3 | Transcription | -2.22 |
Hs.406714 | KRTAP2-4 | Keratin associated protein 2-4 | Cell structure | -2.20 |
Hs.505146 | CLDN14 | Claudin 14 | Cell-cell adhesion | -2.20 |
Hs.799 | HBEGF | Heparin-binding EFG-like growth factor | Growth factor | -2.18 |
Hs.525572 | BDKRB1 | Bradykinin receptor B1 | Inflammatory response | -2.18 |
Hs.191215 | PSCD1 | Pleckstrin homology, Sec7 and coiled-coil domains | Transport | -2.07 |
Hs.76095 | IER3 | Immediate early response 3 | Apoptosis | -2.04 |
Hs.18676 | SPRY2 | Sprouty homolog 2 | Cell-cell signaling | -2.03 |