Skip to main content

Table 2 Down-regulated genes in HPMCs exposed to malignant ascites versus to benign fluids (Fold change > 2, P< 0.05)

From: Role of malignant ascites on human mesothelial cells and their gene expression profiles

Unigene Symbol Description Functions Fold change
Hs.602085 PHLDA1 Pleckstrin homology-like domain, member 1 Nuclear protein -3.40
Hs.624 IL-8 Interleukin 8 Angiogenesis -3.38
Hs.98367 SOX17 SRY-box 17 Transcription -3.33
Hs.345139 GEM GTP binding protein overexpressed in skeletal muscle Intracellular signaling -2.58
Hs.73853 BMP2 Bone morphogenetic protein 2 Cell proliferation -2.58
Hs.251526 CCL7 Chemokine ligand 7 Inflammatory response -2.54
Hs.591159 PTHLH Parathyroide hormone-like hormone Ion binding -2.44
Hs.643357 ADAMTS1 A disintegrin and metallopeptidase with thrombospondin type 1 Cell proliferation -2.34
Hs.517310 RIPK4 Receptor-interacting serine-threonine kinase 4 Intracellular signaling -2.32
Hs.616962 GDF15 Growth differentiation factor 15 Intracellular signaling -2.31
Hs.279522 NR4A3 Nuclear receptor subfamily 4, group A, member 3 Transcription -2.30
Hs.25829 RASD1 RAS, dexamethasone-induced 1 Intracellular signaling -2.27
Hs.516826 TRIB3 Tribbles homolog 3 Transcription -2.22
Hs.406714 KRTAP2-4 Keratin associated protein 2-4 Cell structure -2.20
Hs.505146 CLDN14 Claudin 14 Cell-cell adhesion -2.20
Hs.799 HBEGF Heparin-binding EFG-like growth factor Growth factor -2.18
Hs.525572 BDKRB1 Bradykinin receptor B1 Inflammatory response -2.18
Hs.191215 PSCD1 Pleckstrin homology, Sec7 and coiled-coil domains Transport -2.07
Hs.76095 IER3 Immediate early response 3 Apoptosis -2.04
Hs.18676 SPRY2 Sprouty homolog 2 Cell-cell signaling -2.03