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Table 1 Up-regulated genes in HPMCs exposed to malignant ascites versus to benign fluids (Fold change > 2, P< 0.05)

From: Role of malignant ascites on human mesothelial cells and their gene expression profiles

Unigene Symbol Description Functions Fold change
Hs.425633 CKMT1B Creatine kinase mitochondrial 1B Mitochondria 31.80
Hs.282409 CYP2C19 Cytochrome P450, family 2, subfamily C Electron transport 29.10
Hs.560 APOBEC1 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 mRNA processing 17.19
Hs.516922 NKX2-2 NK2 transcription factor related locus 2 Transcription 16.20
Hs.553484 ANGPT2 Angiopoietin-2A Angiogenesis 16.16
Hs.145932 MTL5 Metallothionein-like 5 Anti-apoptotic 11.40
Hs.445098 DEPDC1 DEP domain containing 1 Intracellular signaling 7.06
Hs.149924 LILRB1 Leucocyte immunoglobulin-like receptor, subfamily B Immune response 6.31
Hs.471494 EIF2C4 mRNA for KIAA1567 Protein synthesis 6.06
Hs.272215 KLF15 Kruppel-like factor 15 Transcription 5.74
Hs.285829 DLEU7 Deleted in lymphocytic leukemia 7 Intracellular signaling 5.23
Hs.6702 KCNB2 Potassium voltage-gated chanel Cation transport 5.08
Hs.351403 DZIP1L DAZ interacting protein 1-like Ion binding 4.60
Hs.479853 EPHA5 EPH receptor A5 Intracellular signaling 4.54
Hs.122583 UTG2A3 UDP glucuronosyltransferase 2 family Metabolism 4.23
Hs.446021 SLC37A3 Solute carrier family 37 Transport 4.02
Hs.270833 AREG Amphiregulin Cell proliferation 3.52
Hs.467793 FLJ40869 Hypothetical protein FLJ40869 DNA repair 3.31
Hs.441975 BIRC4BP XIAP-associated factor 1 Ion binding 3.26
Hs.531941 MYB myeloblastosis viral oncogene homolog Transcription 2.83
Hs.585869 ZNF224 Zinc finger protein 224 Transcription 2.57
Hs.188518 MT1K Metallothionein 1 K Ion binding 2.54
Hs.190043 MOSPD2 Motile sperm domain containing 2 Membrane protein 2.52
Hs.270543 GNB4 Guanine nucleotide binding protein, beta polypeptide 4 Intracellular signaling 2.44
Hs.190622 DDX58 DEAD box polypeptide 58 DNA binding 2.37
Hs.658169 SFRP4 Secreted frizzled-related protein 4 Intracellular signaling 2.37
Hs.13852 DNAJB4 Hsp40 homolog, subfamily B, member 4 Protein folding 2.36
Hs.189920 PB1 Polybromo 1 Transcription 2.35
Hs.513044 CSPG4 Chondroitin sulfate proteoglycan 4 Cell motility 2.32
Hs.520506 FBXO5 F-box protein 5 Protein degradation 2.28
Hs.83634 HCFC1 Host cell factor C1 Cell proliferation 2.25
Hs.14794 ZFP28 Zinc finger protein 28 homolog Transcription 2.19
Hs.10319 UGT2B7 UDP glucuronosyltransferase 2 family Metabolism 2.17
Hs.503093 ZFP36L2 Zinc finger protein 36, C3H type-like 2 Cell proliferation 2.14
Hs.110915 IL22RA1 Interleukin 22 receptor, alpha 1 Immune response 2.13
Hs.442344 IRS2 Insulin receptor substrate 2 Cell proliferation 2.11
Hs.479670 TEC Tec protein tyrosine kinase Intracellular signaling 2.10
Hs.167700 SMAD5 SMAD, family member 5 Transcription 2.10
Hs.541894 ANKRD36 Ankirin repeat domain 36 Catalytic activity 2.09
Hs.655199 MT1A Metallothionein 1A Ion binding 2.09
Hs.407190 FKBP5 FK506 binding protein 5 Protein folding 2.06
Hs.744289 ZNF549 Zinc finger protein 549 Ion binding 2.06
Hs.431550 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 Intracellular signaling 2.04
Hs.433702 EIF5 Eukaryotic translation initiation factor 5 Translation 2.04
Hs.167584 SLC2A2 Solute carrier family 2 Transport 2.03
Hs.405144 SFRS3 Splicing factor, arginine/serine-rich 3 RNA binding 2.02