Figure 5

Network analysis of dynamic gene expression in ascites-stimulated HPMCs based on the common up-regulated (A) or down-regulated (B) (≥ 1.5-fold) gene expression list obtained following stimulation with all three malignant ascites. The top-scoring networks were merged and displayed graphically as node (gene/gene product) and edges (the biological relationships between the nodes). Nodes are displayed using various shapes that represent the functional class of the gene product (square, cytokine; vertical oval, transmembrane receptor; rectangle, nuclear receptor; diamond, enzyme; rhomboid, transporter; hexagon, translation factor; horizontal oval, transcription factor; circle, other). Edges are displayed with various labels that described the nature of relationship between the nodes: — binding only; → acts on. The length of an edge reflects the evidence supporting that node-to-node relationship, in that edges supported by article from literature are shorter. Dotted edges represent indirect interaction.