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Table 1 IC50±SD values (nM) of a panel of low-passaged sarcoma cell lines in response to trabectedin, Zalypsis, and doxorubicin

From: Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

Cell line Tumor origin Doxo (nM) Trabectedin (nM) Zalypsis (nM)
CNIO AW LIPOSARCOMA 45 0.7 ± 0.1 0.16 ± 0.02
CNIO AX LIPOSARCOMA 44 0.7 ± 0.3 0.32 ± 0.15
SW872 LIPOSARCOMA >300 0.5 ± 0.1 0.87 ± 0.53
1455 LIPOSARCOMA >300 0.1 ± 0.02 0.34 ± 0.32
CNIO AA LEYOMYOSARCOMA 21.5 0.4 ± 0.1 0.5 ± 0.13
CNIO AY LEYOMYOSARCOMA 44 9 ± 0.3 2580 ± 1785
CNIO AZ FIBROUS TUMOR 14 5 ± 0.3 870 ± 184.5
CNIO BC MPNST >300 >100 664.75 ± 450.5
CNIO BB MPNST 232 >100 1008.35 ± 353
A673 EWING SARCOMA 50 1 ± 0.07 0.42 ± 0.39
CNIO BJ OSTEOSARCOMA >300 2 ± 0.32 103.2 ± 4.38
CNIO BF OSTEOSARCOMA 15 0.3 ± 0.04 501.95 ± 9.83
CNIO BP OSTEOSARCOMA >300 0.3 ± 0.05 0.29 ± 0.10
SAOS-2 OSTEOSARCOMA >300 0.11 ± 0.02 0.94 ± 0.74
CNIO BG MIXOID FIBROSARC 22 0.3 ± 0.02 1200 ± 565.69
CNIO BM HIBERNOMA >300 10 ± 0.9 3473 ± 169.71
CNIO BN FIBROHISTIOCITOMA >300 >100 4750 ± 70.71
CNIO CE RABDOMIOSARC >300 >100 2401 ± 637.81
CNIO BI GIST 50 0.1 ± 0.02 4933 ± 644.88
  1. The data represent the average IC50 ± SD of three experiments performed independently. In the case of doxorubicin, only the average IC50 is shown. MPNST: Malignant peripheral nerve sheath tumor. GIST: Gastrointestinal stromal tumor.