Table 1 IC50±SD values (nM) of a panel of low-passaged sarcoma cell lines in response to trabectedin, Zalypsis, and doxorubicin
From: Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis
Cell line | Tumor origin | Doxo (nM) | Trabectedin (nM) | Zalypsis (nM) |
|---|---|---|---|---|
CNIO AW | LIPOSARCOMA | 45 | 0.7 ± 0.1 | 0.16 ± 0.02 |
CNIO AX | LIPOSARCOMA | 44 | 0.7 ± 0.3 | 0.32 ± 0.15 |
SW872 | LIPOSARCOMA | >300 | 0.5 ± 0.1 | 0.87 ± 0.53 |
1455 | LIPOSARCOMA | >300 | 0.1 ± 0.02 | 0.34 ± 0.32 |
CNIO AA | LEYOMYOSARCOMA | 21.5 | 0.4 ± 0.1 | 0.5 ± 0.13 |
CNIO AY | LEYOMYOSARCOMA | 44 | 9 ± 0.3 | 2580 ± 1785 |
CNIO AZ | FIBROUS TUMOR | 14 | 5 ± 0.3 | 870 ± 184.5 |
CNIO BC | MPNST | >300 | >100 | 664.75 ± 450.5 |
CNIO BB | MPNST | 232 | >100 | 1008.35 ± 353 |
A673 | EWING SARCOMA | 50 | 1 ± 0.07 | 0.42 ± 0.39 |
CNIO BJ | OSTEOSARCOMA | >300 | 2 ± 0.32 | 103.2 ± 4.38 |
CNIO BF | OSTEOSARCOMA | 15 | 0.3 ± 0.04 | 501.95 ± 9.83 |
CNIO BP | OSTEOSARCOMA | >300 | 0.3 ± 0.05 | 0.29 ± 0.10 |
SAOS-2 | OSTEOSARCOMA | >300 | 0.11 ± 0.02 | 0.94 ± 0.74 |
CNIO BG | MIXOID FIBROSARC | 22 | 0.3 ± 0.02 | 1200 ± 565.69 |
CNIO BM | HIBERNOMA | >300 | 10 ± 0.9 | 3473 ± 169.71 |
CNIO BN | FIBROHISTIOCITOMA | >300 | >100 | 4750 ± 70.71 |
CNIO CE | RABDOMIOSARC | >300 | >100 | 2401 ± 637.81 |
CNIO BI | GIST | 50 | 0.1 ± 0.02 | 4933 ± 644.88 |