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Table 1 SUPO Score for the classification of rhagades

From: Randomized controlled trial to evaluate the effects of ethyl-2-cyanoacrylate on pain intensity and quality of life in head and neck cancer patients suffering from cetuximab-induced rhagades during radioimmunotherapy: the support trial

Grade 1: Rhagades without clinical symptoms
Grade 2: Painful rhagades
  Grade 2a: Moderate pain, no impairment of activity in the daily routine (ADL)
  Grade 2b: Severe pain and impairment of the activities of daily living (ADL)
Grade 3: Painful, deep and spontaneously bleeding rhagades
Grade 4: Superinfection of the rhagades (detection of bacterial growth)
  Grade 4a: Local infection
  Grade 4b: Systemic infection
Grade 5: Death due to complications of the rhagades