|  |  | Overall Survival (OS) | Disease Free Survival (DFS) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Univariate (OS) | Multivariate (OS) | Univariate (DFS) | Multivariate (DFS) | ||||||||
Parameter | Â | n | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value |
Clinical data (total) | Â | 262 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Age in years | <65 | 109 | 1.000 | Â | 0.000 | 1.000 | Â | 0.000 | 1.000 | Â | 0.000 | 1.000 | Â | 0.000 |
 | ≥65 | 153 | 3.381 | 2.360-4.842 |  | 3.648 | 2.537-5.245 |  | 3.058 | 2.172-4.307 |  | 3.309 | 2.338-4.682 |  |
TNM | Stage I | 47 | 1.000 | Â | 0.000 | 1.000 | Â | 0.000 | 1.000 | Â | 0.000 | 1.000 | Â | 0.000 |
 | Stage II | 97 | 1.522 | 0.910-2.547 |  | 1.699 | 1.013-2.850 |  | 1.513 | 0.927-2.469 |  | 1.686 | 1.030-2.760 |  |
 | Stage III/IV | 118 | 3.590 | 2.208-5.838 |  | 4.034 | 2.473-6.580 |  | 3.199 | 2.006-5.102 |  | 3.560 | 2.223-5.700 |  |
DifferentiationI | Grade 1 | 49 | 1.000 | Â | 0.451 | Â | Â | Â | 1.000 | Â | 0.663 | Â | Â | Â |
 | Grade 2+ | 158 | 1.174 | 0.773-1.783 |  |  |  |  | 1.093 | 0.733-1.630 |  |  |  |  |
MSIII | MSS | 184 | 1.000 | Â | 0.457 | Â | Â | Â | 1.000 | Â | 0.429 | Â | Â | Â |
 | MSI | 26 | 0.816 | 0.477-1.396 |  |  |  |  | 0.815 | 0.491-1.353 |  |  |  |  |
SizeIII in mm | <50 | 179 | 1.000 | Â | 0.589 | Â | Â | Â | 1.000 | Â | 0.396 | Â | Â | Â |
 | ≥50 | 82 | 1.093 | 0.791-1.511 |  |  |  |  | 1.146 | 0.837-1.568 |  |  |  |  |
MucinousIV | No | 220 | 1.000 | Â | 0.447 | Â | Â | Â | 1.000 | Â | 0.248 | Â | Â | Â |
 | yes | 36 | 0.850 | 0.558-1.293 |  |  |  |  | 0.790 | 0.529-1.179 |  |  |  |  |
uPAR in tumor cells | Low | 152 | 1.000 | Â | 0.036 | 1.000 | Â | 0.177 | 1.000 | Â | 0.037 | 1.000 | Â | 0.318 |
 | High | 110 | 1.387 | 1.021-1.883 |  | 1.241 | 0.907-1.697 |  | 1.372 | 1.019-1.848 |  | 1.168 | 0.861-1.585 |  |
uPAR in stromal cells | Neg | 38 | 1.000 | Â | 0.033 | 1.000 | Â | 0.067 | 1.000 | Â | 0.014 | 1.000 | Â | 0.031 |
 | Pos | 224 | 1.688 | 1.044-2.729 |  | 1.580 | 0.968-2.578 |  | 1.819 | 1.127-2.936 |  | 1.713 | 1.049-2.796 |  |
Combined uPAR expressionV | Neg | 38 | 1.000 | Â | 0.032 | 1.000 | Â | 0.037 | 1.000 | Â | 0.019 | 1.000 | Â | 0.032 |
 | Pos/Low | 119 | 1.508 | 0.909-2.501 |  | 1.503 | 0.905-2.495 |  | 1.646 | 0.995-2.724 |  | 1.661 | 1.002-2.754 |  |
 | Pos/High | 105 | 1.925 | 1.159-3.198 |  | 1.906 | 1.146-3.170 |  | 2.036 | 1.230-3.370 |  | 1.959 | 1.182-3.247 |  |