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Figure 8 | BMC Cancer

Figure 8

From: RETRACTED ARTICLE: Identification of novel signaling components in N,N’-Dinitrosopiperazine-mediated metastasis of nasopharyngeal Carcinoma by quantitative phosphoproteomics

Figure 8

Phospho-LYRIC and LYRIC expression in the metastatic tumors induced by DNP. The metastatic tumor samples were embedded. Tissue sections of 4-μm thickness were prepared, and deparaffinized in xylene, and rehydrated in a graded alcohol series. Phospho-LYRIC and LYRIC were detected in these sections using immunohistochemistry. A, Paraffin sections were stained with hematoxylin and eosin as well as with antibodies against or LYRCI or phospho-LYRIC S568. a, c and e, The untreated 6-10B cells (NPC in situ) used as control; b, d and f, The DNP-treated 6-10B cells. Arrow, positive cell. Magnification, × 400. Scale bar, 5 μm. H & E, hematoxylin and eosin. B, Phospho-LYRIC was quantified in the nucleus and cytoplasm of metastatic tumor cells by using ImageMaster software, and phospho-LYRIC rates of nucleus to cytoplasm were calculated. C, Schematic illustration of DNP-induced metastasis. DNP-mediated LYRIC phosphorylation increases the motility and invasion, leading to metastasis of NPC cells.

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BMC Cancer

ISSN: 1471-2407

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