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Figure 3 | BMC Cancer

Figure 3

From: Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

Figure 3

Anti-IL17A treatment down regulates pro-inflammatory cytokines associated with IL-17A expression. A-C: Levels of IL-17A (pgs/ml) by ELISA in the tumor, lung and bone protein lysates of SKG mice (*P < 0.05;**P < 0.01). D-F: Levels of IL-17A by ELISA in the tumor, lung and bone of PyV MT mice (**P < 0.01; *P < 0.05). The limit of detection for mouse IL-17A is 4 pg/ml to 500 pg/ml. G-J: Ray Biotech cytokine array densitometry values: G and H: 4 T1 tumor bearing SKG mice. I and J: Arthritic PyV MT mice (*P <0.05, **P < 0.01, ***P < 0.001). N = 4 mice.

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