Figure 6

Effect of AK2 knockdown on the glucose uptake and lactate production by UM1 and UM2 cells. A significantly higher amount of glucose was consumed by UM1 cells (n = 5, p = 0.002) and UM2 cells (n = 5, p = 0.03) when cellular AK2 expression was inhibited by siRNA. Meanwhile, siAK2-transfected UM1 (n = 5, p = 0.02) and UM2 cells (n = 5, p = 0.09) produced more lactate than the siCTRL-transfected cells.