Impairment of cognitive functioning during Sunitinib or Sorafenib treatment in cancer patients: a cross sectional study

Table 1 Characteristics of the study groups

	Patients VEGFR TKI (n = 30)		Patient controls (n = 20)		Healthy controls (n = 30)		P
Characteristics
Age, years
Mean	60		62		58		0.456^e
Range	38-81		30-75		45-73		0.456^e
Sex (%)
Male	27	(90)	15	75	26	(87)	0.329^f
Female	3	(10)	5	25	4	(13)	0.329^f
Median education level (SD)^d	4	(1.21)	5	(1.12)	5	(0.80)	0.546^g
Estimation IQ (SD)	102.30	(10.37)	106.20	(10.55)	106.37	(8.09)
Median free testosterone^c pmol/L (IQR 25-75)	165.00	(129,5-238.00)	237.50	(200.75-299.25)	-	-	0.005^a
Median estradiol pmol/l^† (IQR 25-75)	48.00	(42-55)	78.50	(78.5-112.5)	-	-	0.000 ^a
Median albumin g/l (IQR 25-75)	39.00	(34.50-40.25)	37.50	(35.25-40.00)	-	-	0.599^a
Median CRP mg/l (IQR 25-75)	10.00	(4.00-21.75)	5.00	(4.00-38.25)	-	-	0.849^{a, b}
Median absolute neutrophil count 10⁹/l (IQR 25-75)	2.95	(2.08-3.66)	3,89	(3.43-5.64)	-	-	0.009^a
Median ESR mm/hour (IQR 25-75)	20.00	(8.75-34.50)	19.00	(7.00-31.00)	-	-	0.767^{a, b}
Median glucose mmol/l (IQR 25-75)	5.6	(4.9-5.98)	5.8	(5.35-7.55)	-	-	0.010^a
Median TSH mE/l (IQR 25-75)	2.29	(1.49-3.63)	1.12	(0.78-2.04)	-	-	0.003^{a, b}
Median LDH U/l (IQR 25-75)	463.50	(402.25-526.50)	346.50	(314.50-458.00)	-	-	0.008^{a, b}
Median VEGF ng/ml (IQR 25-75)	1.62	(1.09-2.18)	1.48	(1.21-2.00)	-	-	0.221^a

^aT-test between the two patients groups; ^bcalculated with the logaritmic values.
^ccalculated free testosterone only in men, reference value for men: 120-630 pmol/l, ^†estradiol level only in men, reference value 75-220 pmol/l. Abbreviations: SD Standard deviation, IQR inter quartile range 25^e and 75^e percentile, ESR erythrocyte sedimentation rate, CRP C-reactive protein, LDH lactate dehydrogenase, VEGF vascular endothelial growth factor.
^dEducation levels as assessed using 7 categories in accordance with the Dutch educational system (1 = less than primary school; 7 = academic degree); ^eANOVA; ^fChi-square test; ^gKruskal-Wallis Test.

ISSN: 1471-2407