Figure 1

Nucleostemin (NS) expression in human breast cancer tissues. A. A NS-positive tumor. Almost all cancer cells show NS immunoreactivity in both nucleoli and nucleoplasm. B. Another NS-positive tumor, NS immunoreactivity is limited to nucleoli in nuclei of cancer cells. Such cancer cells are also judged as NS-positive. This case was also classified as NS-positive. C. A NS-negative tumor. D. An unremarkable mammary gland shows nuclear NS immunoreactivity in almost all luminal epithelial cells.