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Table 2 Odds ratios (OR) and 95% confidence intervals (CI) from a fully saturated discrete-time logistic regression model, comparing the risk of a first cancer in the general population with that of a second cancer in skin cancer survivors

From: New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

 

CMM

SCC

 

Events/Pyr1

OR (95% CI)

Events/Pyr

OR (95% CI)

Primary skin cancer

    

 No

143 978/31.0 mill

1.00 ref

144 179/31.0 mill

1.00 ref

 Yes

3662/288 823

1.53 (1.48,1.59)

5612/175 641

2.30 (2.22,2.37)

Sex

    

 Female

72 768/15.8 mill

1.00 ref

72 319/15.7 mill

1.00 ref

 Male

75 206/15.4 mill

1.28 (1.26,1.29)

77 472/15.4 mill

1.31 (1.29,1.32)

Age 2

    

 20-40 years

6447/12.0 mill

1.00 ref

6509/12.0 mill

1.00 ref

 40-59 years

30 795/10.6 mill

5.37 (5.22,5.52)

30 241/10.5 mill

5.28 (5.14,5.43)

 ≥ 60 years

110 732/8.6 mill

20.58 (20.04,21.14)

113 041/8.6 mill

20.34 (19.80,20.9)

Residential region 3

    

 North

21 277/6.0 mill

1.00 ref

21 323/6.0 mill

1.00 ref

 Mid

34 586/7.2 mill

1.30 (1.27,1.32)

34878/7.2 mill

1.30 (1.28,1.32)

 South

92 111/18.0 mill

1.33 (1.31,1.35)

93 590/17.9 mill

1.35 (1.33,1.37)

Calendar period 2

    

 < 1965

8477/4.3 mill

1.00 ref

8354/4.3 mill

1.00 ref

 1965-1974

20 484/5.4 mill

2.54 (2.47,2.61)

20 867/5.4 mill

2.62 (2.56,2.6)

 1975-1984

27 276/5.9 mill

3.63 (3.54,3.73)

27 573/5.9 mill

3.73 (3.63,3.83)

 1985-1994

33 071/6.3 mill

4.28 (4.17,4.40)

33 817/6.3 mill

4.45 (4.34,4.57)

 1995-2004

40 142/6.6 mill

5.33 (5.19,5.47)

40 241/6.6 mill

5.41 (5.27,5.56)

 ≥ 2005

18 524/2.7 mill

5.99 (5.82,6.17)

18 939/2.6 mill

6.22 (6.04,6.40)

Educational level 4

    

 ≤ Primary school

15 926/1.9 mill

1.00 ref

16 141/1.9 mill

1.00 ref

 Secondary school

67 042/11.8 mill

0.32 (0.31,0.33)

67 915/11.8 mill

0.32 (0.31,0.33)

 Some college

35 646/7.0 mill

0.30 (0.29,0.31)

36 079/7.0 mill

0.30 (0.29,0.30)

 ≥ College degree

29 360/10.5 mill

0.30 (0.29,0.31)

29 656/10.4 mill

0.30 (0.30,0.31)

Marital status 3

    

 Not married

47 085/15.7 mill

1.00 ref

47 881/15.7 mill

1.00 ref

 Married

100 889/15.5 mill

1.25 (1.24,1.27)

101 910/15.4 mill

1.27 (1.25,1.28)

Parental status 4

    

 No children

138 424/28.9 mill

1.00 ref

139 451/28.9 mill

1.00 ref

 Children

9550/2.3 mill

0.95 (0.93,0.97)

10 340/2.2 mill

0.96 (0.94,0.98)

Income (annual) 3

    

 $ 05

60 395/9.1 mill

1.00 ref

62 871/9.1 mill

1.00 ref

 $ 80–9 999

40 528/10.7 mill

0.92 (0.90,0.93)

40 556/10.7 mill

0.91 (0.90,0.92)

 $ 10 000–19 999

34 425/8.7 mill

0.80 (0.79,0.82)

34 394/8.7 mill

0.80 (0.78,0.80)

 $ 20 000–39 999

11 582/2.6 mill

0.78 (0.77,0.80)

11 140/2.5 mill

0.76 (0.74,0.78)

 $ ≥ 40 000

1044/153 034

0.82 (0.77,0.87)

830/122 013

0.78 (0.73,0.84)

  1. 1Number of events (new cancers) per person-year during follow-up. 2Time-varying covariates (yearly). 3At start of follow-up. 4At end of follow-up. 5Includes also those with missing income data.