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Figure 1 | BMC Cancer

Figure 1

From: Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis

Figure 1

Immunohistochemical analysis of MEKK3 in esophageal tissues. Paraffin-embedded sections of histologically normal mucosa, dysplasia, and ESCC were stained using anti-MEKK3 polyclonal antibody as described in the Methods section. (i) Normal esophageal mucosa showing no MEKK3 immunostaining; (ii) dysplasia depicting nuclear and cytoplasmic MEKK3 immunostaining in epithelial cells; (iii) ESCC illustrating both intense cytoplasmic and nuclear staining in tumor cells; (iv) ESCC section showing cytoplasmic MEKK3 immunostaining; (v) ESCC used as a negative control incubated with isotype specific IgG replacing the primary antibody showing no MEKK3 immunostaining in tumor cells ((i-v) original magnification x 200).

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BMC Cancer

ISSN: 1471-2407

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