Serum soluble ST2 is associated with ER-positive breast cancer

BMC Cancer

Table 2 Clinicopathological factors associated with disease-free survival and overall survival in patients with ER-positive breast cancer

Parameter	N(total = 103)	Disease-free survival			Overall survival
		Hazard ratio	(95% CI)	P-value	Hazard ratio	(95% CI)	P-value
Age (years)
<50 years old	45	1			1
≥50 years old	58	1.352	0.262-6.976	0.719	0.275	0.025-3.037	0.292
Histological type
IBC	91	1			1
DCIS	12	0.044	0.000-1.173E6	0.721	0.044	0.000-2.452E12	0.846
Stage
0, I and II	88	1			1
III	15	1.782	0.345-9.194	0.490	2.218	0.201-24.536	0.516
Tumor size (cm)
≤2 cm	49	1			1
>2 cm	54	0.460	0.096-2.196	0.330	0.136	0.011-1.636	0.116
Lymphonodus status
Positive	70	1			1
Negative	33	2.834	0.539-14.891	0.219	2.366	0.205-27.247	0.490
PR status
Positive	99	1			1
Negative	4	0.046	0.000-6.748E5	0.715	0.046	0.000-9.501E8	0.799
Tissue Her-2
Positive	10	1			1
Negative	93	31.064	0.011-8.581E4	0.395	32.686	0.000-3.286E6	0.533
Ki67 status
>14%(+)	74	1			1
≤14% (+)	29	1.229	0.238-6.339	0.805	1.506	0.0136-16.627	0.738
sST2 status
High	48	1			1
Low	55	2.371	0.520-10.812	0.265	147.956	0.006-3.743E5	0.334
IL-33 status
High	23	1			1
Low	80	0.988	0.190-5.126	0.988	0.870	0.078-9.696	0.910
VEGF status
High	47	1			1
Low	56	1.308	0.119-14.437	0.826	0.516	0.115-2.309	0.387

Abbreviation: No = number, IBC = invasive breast cancer, T = tumor size, Tis: tumor in situ, DCIS: ductal carcinoma in situ, ER = estrogen receptor, PR = progesterone receptor, Her-2 = human epithelial receptor-2, CI = Confidence interval.
P < 0.05, indicated a significant association.

ISSN: 1471-2407