| | |
Subcohort
|
Head-neck cancer cases
|
|---|
| | | |
Overall
|
Subtypes
| | |
|---|
| | | | | |
OCCb
| |
OHPCb
| |
LCb
| | |
|---|
| |
Categorical median
|
Person time at risk (years)
|
No. of cases
|
RR (95% CI)
|
No. of cases
|
RR (95% CI)
|
No. of cases
|
RR (95% CI)
|
No. of cases
|
RR (95% CI)
|
Pfor heterogeneity
|
|---|
|
Alcohol consumption (grams ethanol/day)
|
|
Abstainers
|
0
|
15 255
|
49
|
1 (reference)
|
12
|
1 (reference)
|
11
|
1 (reference)
|
26
|
1 (reference)
|
0.86
|
|
>0 to <5
|
2
|
19 008
|
67
|
1.11 (0.75-1.65)
|
17
|
1.25 (0.59-2.65)
|
14
|
1.06 (0.47-2.40)
|
36
|
1.03 (0.60-1.77)
| |
|
5 to <15
|
9
|
14 468
|
72
|
1.15 (0.77-1.71)
|
19
|
1.91 (0.91-4.03)
|
12
|
0.90 (0.38-2.13)
|
40
|
0.94 (0.56-1.58)
| |
|
15 to <30
|
22
|
9 961
|
92
|
1.52 (1.02-2.27)
|
30
|
3.88 (1.86-8.12)
|
13
|
0.99 (0.41-2.38)
|
49
|
1.10 (0.66-1.83)
| |
|
≥30
|
40
|
5 659
|
115
|
2.74 (1.85-4.06)
|
32
|
6.39 (3.13-13.03)
|
33
|
3.52 (1.69-7.36)
|
48
|
1.54 (0.91-2.60)
| |
|
P for trendc
| | | |
<0.001
| |
<0.001
| |
<0.001
| |
0.05
| |
|
Continuous, 10 gram
| | | | | | | | | | | |
|
ethanol/day increments
| | | | | | | | | | | |
|
Overall
| |
64 352
|
395
|
1.20 (1.12-1.27)
|
110
|
1.28 (1.18-1.39)
|
83
|
1.27 (1.16-1.38)
|
199
|
1.10 (1.02-1.18)
|
0.18
|
|
Men
| |
30 169
|
314
|
1.19 (1.12-1.27)
|
65
|
1.27 (1.17-1.38)
|
61
|
1.27 (1.16-1.39)
|
187
|
1.10 (1.03-1.19)
| |
|
Women
| |
34 183
|
81
|
1.40 (1.18-1.65)
|
45
|
1.58 (1.33-1.87)
|
22
|
1.31 (0.91-1.87)
|
12
|
0.85 (0.46-1.59)
| |
|
P for interactiond
| | | |
0.02
| |
0.004
| |
0.68
| |
0.67
| |
|
Alcohol consumption (grams ethanol/day)
stable users
e
|
|
Abstainers
|
0
|
11 810
|
38
|
1 (reference)
|
9
|
1 (reference)
|
9
|
1 (reference)
|
20
|
1 (reference)
|
1.00
|
|
>0 to <5
|
2
|
11 813
|
36
|
0.98 (0.60-1.61)
|
12
|
1.65 (0.68-4.01)
|
7
|
0.86 (0.30-2.41)
|
17
|
0.72 (0.35-1.46)
| |
|
5 to <15
|
9
|
8 749
|
38
|
0.96 (0.58-1.59)
|
9
|
1.68 (0.63-4.47)
|
8
|
0.89 (0.32-2.47)
|
21
|
0.72 (0.37-1.40)
| |
|
15 to <30
|
22
|
5 293
|
45
|
1.27 (0.76-2.11)
|
12
|
3.20 (1.25-8.19)
|
6
|
0.72 (0.23-2.26)
|
27
|
0.96 (0.50-1.83)
| |
|
≥30
|
42
|
3 047
|
69
|
2.90 (1.78-4.73)
|
17
|
7.50 (3.15-17.88)
|
20
|
3.46 (1.46-8.20)
|
31
|
1.57 (0.82-3.02)
| |
|
P for trend
| | | |
<0.001
| |
<0.001
| |
0.001
| |
0.03
| |
|
Continuous, 10 grams
| |
39712
|
226
|
1.26 (1.16-1.36)
|
59
|
1.37 (1.24-1.52)
|
50
|
1.35 (1.20-1.52)
|
116
|
1.16 (1.04-1.28)
|
0.72
|
|
ethanol/day increments
| | | | | | | | | | | |
|
Alcoholic beverages (glasses/day)
f
|
|
Beer
| | | | | | | | | | | |
|
No beer
|
0
|
43 519
|
183
|
1 (reference)
|
59
|
1 (reference)
|
36
|
1 (reference)
|
87
|
1 (reference)
|
0.84
|
|
>0- < 1
|
0.2
|
16 408
|
129
|
0.94 (0.71-1.24)
|
34
|
1.10 (0.65-1.86)
|
24
|
0.98 (0.54-1.76)
|
69
|
0.85 (0.60-1.22)
| |
|
1- < 2
|
1.4
|
2 853
|
37
|
1.12 (0.72-1.74)
|
8
|
1.17 (0.49-2.77)
|
6
|
1.04 (0.41-2.66)
|
23
|
1.19 (0.71-2.01)
| |
|
≥2
|
3.4
|
1 554
|
46
|
1.39 (0.83-2.34)
|
9
|
0.99 (0.34-2.82)
|
17
|
2.48 (1.03-5.98)
|
20
|
1.30 (0.69-2.46)
| |
|
P for trend
| | | |
0.14
| |
0.95
| |
0.03
| |
0.20
| |
|
Continuous, 1
| |
64 335
|
395
|
1.07 (0.97-1.19)
|
110
|
0.97 (0.80-1.16)g
|
83
|
1.19 (1.01-1.40)
|
199
|
1.08 (0.96-1.23)
|
0.07
|
|
glass/day increments
| | | | | | | | | | | |
|
Wine
| | | | | | | | | | | |
|
No wine
|
0
|
30 263
|
197
|
1 (reference)
|
44
|
1 (reference)
|
38
|
1 (reference)
|
114
|
1 (reference)
|
0.93
|
|
>0- < 1
|
0.2
|
25 975
|
132
|
0.88 (0.67-1.14)
|
40
|
1.07 (0.67-1.71)
|
33
|
1.01 (0.59-1.75)
|
57
|
0.74 (0.52-1.05)
| |
|
1- < 2
|
1.4
|
5 277
|
39
|
0.95 (0.63-1.44)
|
14
|
1.31 (0.67-2.55)
|
5
|
0.52 (0.19-1.39)
|
20
|
1.07 (0.63-1.83)
| |
|
≥2
|
2.6
|
2 751
|
24
|
0.56 (0.29-1.07)
|
11
|
0.93 (0.34-2.57)
|
7
|
0.52 (0.15-1.81)g
|
6
|
0.39 (0.15-0.99)
| |
|
P for trend
| | | |
0.15
| |
0.93
| |
0.16
| |
0.21
| |
|
Continuous, 1
| |
64 265
|
392
|
0.88 (0.74-1.05)
|
109
|
0.89 (0.69-1.16)
|
83
|
0.86 (0.64-1.17)
|
197
|
0.88 (0.68-1.14)
|
0.26
|
|
glass/day increments
| | | | | | | | | | | |
|
Liquor
| | | | | | | | | | | |
|
No liquor
|
0
|
33 299
|
137
|
1 (reference)
|
40
|
1 (reference)
|
34
|
1 (reference)
|
63
|
1 (reference)
|
0.44
|
|
>0- < 1
|
0.2
|
23 492
|
133
|
1.09 (0.84-1.43)
|
31
|
1.10 (0.67-1.80)
|
23
|
0.86 (0.48-1.53)
|
78
|
1.17 (0.81-1.67)
| |
|
1- < 2
|
1.9
|
5 370
|
67
|
1.09 (0.76-1.57)
|
18
|
1.65 (0.87-3.15)
|
12
|
0.79 (0.39-1.62)
|
37
|
1.08 (0.67-1.74)
| |
|
≥2
|
2.8
|
2 115
|
56
|
1.18 (0.71-1.95)
|
20
|
2.26 (1.02-4.99)
|
14
|
0.83 (0.33-2.13)
|
20
|
0.95 (0.47-1.93)
| |
|
P for trend
| | | |
0.61
| |
0.03
| |
0.64
| |
0.83
| |
|
Continuous, 1
| |
64 275
|
393
|
1.01 (0.86-1.18)
|
109
|
1.18 (0.89-1.56)
|
83
|
0.89 (0.68-1.15)
|
198
|
0.98 (0.80-1.21)
|
0.25
|
|
glass/day increments
| | | | | | | | | | | |
-
aAdjusted for age (years), sex, cigarette smoking (status (never/former/current), frequency (continuous; centered), and duration (continuous; centered)).
-
bOCC: oral cavity cancer; OHPC: oro-/hypopharyngeal cancer; LC: laryngeal cancer.
-
cTests for dose-response trends were assessed by fitting ordinal variables as continuous terms in the Cox proportional hazards model.
-
d
P Value for interaction between sex and alcohol consumption, based on cross-product terms in the Cox proportional hazards model and Wald test.
-
eSubjects who had not changed their continuous alcohol consumption habits in the 5 years before baseline: for “beer” and “other alcoholic beverages”, participants could indicate whether 5 years before baseline they drunk (1) more than, (2) equal amounts of or (3) less than at baseline; the fourth answer option was (4) “I never use this”.
-
fAdditionally adjusted for continuous ethanol intake (g ethanol/day).
-
gProportional hazards assumption was possibly violated for the exposure variable, and there was a statistically significant interaction with time.
