Table 1 PTEN status in endometrial cancer cell lines
| Â | PTEN status | |||
|---|---|---|---|---|
Histological subtypes | Cell lines | Codon | Mutation | Predictive effect |
Endometrioid adenocacioma | HEC-6 | INTRON 4 (+2) | T TO C | Splice donor |
| Â | 289 | 1bp (A) del | Frameshift | |
HEC-59 | 41 | TAC to TAC | Tyr (Y) to His (H) | |
| Â | 233 | CGA to TGA | Stop | |
| Â | 246 | CCG to CTG | Pro (P) to Leu (L) | |
| Â | 267 | 1bp (A) del | Frameshift | |
HEC-88 | 130 | CGA to GGA | Arg (R) to Gly (G) | |
| Â | 173 | CGC to TGC | Arg (R) to Cys (C) | |
| Â | 310 | GAT to TAT | Asp (D) to Tyr (Y) | |
| Â | 341 | TTT to TGT | Phe (F) to Cys (C) | |
HEC-108 | 6 | 2bp (AA) del | Frameshift | |
| Â | 289 | 1bp (A) del | Frameshift | |
HEC-116 | Intron 2 (-1) | G to A | Splice acceptor | |
| Â | 173 | CGC to TGC | Arg (R) to Cys (C) | |
| Â | 233 | CGA to TGA | Stop | |
HEC-151 | 33 | 3bp (ATT) del | In frame deletion | |
| Â | 76 | 2bp (AT) del | Frameshift | |
HHUA | 164 | 1bp (A) del | Frameshift | |
| Â | 289 | 1bp (A) del | Frameshift | |
AN3CA | 130 | 1bp (G) del | Nonsence | |
Ishikawa3-H-12 | 289 | 1bp (A) del | Frameshift | |
| Â | 317-318 | 4bp (ACTT) del | Frameshift | |
RL95-2 | 322 | 1bp (A) del and 1bp (A) ins | Frameshift | |
HEC-251 | 10 | AGC to AAC | Ser (S) to Asn (N) | |
HEC-265 | 319 | 1bp (A) ins | Frameshift | |
KLE | WT | None | Â | |
HEC-1B | WT | None | Â | |
HEC-50B | WT | None | Â | |
Serous adenocarcinoma | HEC-180 | WT | None | Â |