Effect of ShCCND1 on tumor growth in the xenograft mouse model. Gross observation of ShCCND1 xenografts showed a smaller volume compared to that of ShScramble xenografts (A). Tumor volume of ShCCND1 xenografts was decreased compared to that of ShScramble xenografts during the experiment (B). Tumor weight of ShCCND1 xenografts was significantly decreased compared to that of ShScramble xenografts (C). The data presented are the mean ± SEM. **P < 0.01 and ***P < 0.001 versus the ShScramble-transduced cells.