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Figure 3 | BMC Cancer

Figure 3

From: Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

Figure 3

Impairment of DNA damage repair following irradiation. (A) U251 cells were pretreated with the indicated inhibitors plus TMZ before assessment of γH2AX foci formation. Mock-treated control cells were analyzed 6 h after irradiation with 6 Gy. Pretreatment of U251 cells with the dual inhibitor PI103, the HSP90 inhibitor 17-DMAG, or the HDAC inhibitor LBH589 plus TMZ caused marked prolongation of radiation-induced γH2AX foci formation 6 h after 6Gy irradiation. (B) Pretreatment of U251 cells with TMZ combined with PI103, 17-DMAG, or LBH589 attenuated p-DNA-PK expression.

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BMC Cancer

ISSN: 1471-2407

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