From: Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis
 |  |  | T category (T3,4 vs. T1,2) |  | N category (H vs. L) |  | M category (H vs. L) |  | Grade (G3 vs. G1,2) |  | DFS (death vs. survive) |  | OS 3 year (death vs. survive) |  | OS 5 year (death vs. survive) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | N1 | RR(95% CI) | N2 | RR(95% CI) | N3 | RR(95% CI) | N4 | RR(95% CI) | N5 | RR(95% CI) | N6 | RR(95% CI) | N7 | RR(95% CI) |
Over all | Â | 13 | 1.15 (0.97, 1.35) | 23 | 1.39 (1.07, 1.81) | 4 | 1.79 (0.76, 4.26) | 7 | 1.47 (1.00, 2.14) | 5 | 1.50 (0.83, 2.71) | 10 | 0.76 (0.59, 0.99) | 12 | 0.76 (0.55, 1.05) |
Cancer type | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Oral | Â | 2 | 0.75 (0.48, 1.16) | 9 | 0.82 (0.54, 1.25) | 2 | 1.99 (0.99, 3.99) | 2 | 0.91 (0.50, 1.67) | 4 | 1.86 (1.47, 2.37) | 3 | 0.85 (0.49, 1.47) | 5 | 0.91 (0.46, 1.78) |
Larynx | Â | 8 | 1.33 (1.01, 1.76) | 11 | 2.53 (1.99, 3.21) | - | - | 4 | 2.13 (0.99, 4.58) | - | - | 5 | 0.87 (0.62, 1.23) | 5 | 0.62 (0.47, 0.83) |
Pharynx & Larynx | Â | 11 | 1.21 (1.08, 1.35) | 14 | 1.95 (1.35, 2.82) | 2 | 1.77 (0.13, 23.59) | 5 | 1.71 (1.04, 2.79) | 1 | 0.53 (0.29, 0.97) | 7 | 0.72 (0.52, 0.99) | 7 | 0.66 (0.47, 0.94) |
Geographic area | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asia | Over all | 9 | 1.39 (1.17, 1.64) | 16 | 1.81 (1.26, 2.61) | 3 | 1.82 (0.59, 5.63) | 6 | 1.61 (1.01, 2.57) | 2 | 0.98 (0.28, 3.4) | 4 | 0.71 (0.56, 0.89) | 4 | 0.8 (0.57, 1.14) |
Oral | - | Â | 3 | 0.75 (0.10, 5.62) | 1 | 2.03 (0.99, 4.17) | 1 | 0.72 (0.02, 4.33) | 1 | 1.87 (0.9, 3.88) | - | - | - | - | |
Larynx | 6 | 1.60 (1.14, 2.25) | 10 | 2.39 (1.65, 3.45) | - | - | 4 | 2.13 (0.99, 4.58) | - | - | 3 | 0.77 (0.66, 0.9) | 3 | 0.69 (0.52, 0.91) | |
Larynx & pharynx | 9 | 1.39 (1.17, 1.64) | 13 | 1.98 (1.33, 2.95) | 2 | 1.77 (0.13, 23.59) | 5 | 1.71 (1.04, 2.79) | 1 | 0.53 (0.29, 0.97) | 4 | 0.71 (0.56, 0.89) | 4 | 0.8 (0.57, 0.94) | |
Europe & USA | Over all | 3 | 0.88 (0.76, 1.02) | 6 | 0.90 (0.68, 1.20) | 1 | 1.46 (0.09, 22.93) | 1 | 1.03 (0.56, 1.92) | 2 | 3.08 (0.74, 12.78) | 6 | 0.78 (0.48, 1.27) | 8 | 0.64 (0.35, 1.16) |
Oral | 1 | 0.57 (0.30, 1.11) | 5 | 0.73 (0.52, 1.02) | 1 | 1.46 (0.09, 22.93) | 1 | 1.03 (0.56, 1.92) | 2 | 3.08 (0.74, 12.78) | 3 | 0.85 (0.49, 1.47) | 5 | 0.90 (0.46, 1.78) | |
Larynx | 2 | 0.96 (0.85, 1.08) | 1 | 1.85 (1.07, 3.18) | - | - | - | - | - | - | 2 | 0.96 (0.24, 3.88) | 2 | 0.46 (0.29, 0.72) | |
Larynx & pharynx | 2 | 0.96 (0.85, 1.08) | 1 | 1.85 (1.07, 3.18) | - | - | - | - | - | - | 3 | 0.61 (0.15, 2.5) | 3 | 0.36(0.23, 0.57) | |
Oral | Pan-CD44 | 2 | 0.75 (0.48, 1.16) | 3 | 0.58 (0.37, 0.92) | 2 | 1.99 (0.99, 3.99) | 2 | 0.91 (0.5, 1.67) | 2 | 1.65 (1.68, 2.13) | 3 | 0.85 (0.49, 1.47) | 4 | 0.69 (0.32, 1.52) |
 | CD44-6 | - | - | 2 | 0.79 (0.29, 2.12) | - | - | - | - | - | - | - | - | - | - |
Larynx | Pan-CD44 | 5 | 1.25 (0.90, 1.73) | 6 | 2.83 (2.01, 3.98) | 2 | - | 4 | 2.13 (0.99, 4.58) | - | - | 5 | 0.87 (0.62, 1.23) | 3 | 0.66 (0.46, 0.95) |
 | CD44-6 | 2 | 1.34 (0.99, 1.82) | 4 | 1.92 (1.39, 2.64) | - | - | - | - | - | - | - | - | 2 | 0.53 (0.37, 0.77) |
Larynx & pharynx | Pan-CD44 | 6 | 1.23 (0.92, 1.65) | 7 | 2.74 (1.98, 3.81) | 1 | 6.65 (0.93, 47.63) | 4 | 2.13 (0.99, 4.58) | 1 | 0.53 (0.29, 0.97) | 6 | 0.794 (0.56, 1.1) | 4 | 0.56 (0.34, 0.93) |
 | CD44-6 | 3 | 1.15 (0.90, 1.48) | 5 | 1.47 (0.90, 2.42) | 1 | 1.03 (0.94, 1.13) | - | - | - | - | - | - | 2 | 0.53 (0.37, 0.77) |
Sample size a | <58.5 | 4 | 1.79 (0.82, 3.89) | 10 | 1.388 (0.83, 2.33) | 1 | 6.65 (0.93, 47.63) | 3 | 1.34 (0.5, 3.58) | 3 | 1.71 (0.44, 6.69) | 3 | 0.34 (0.21, 0.54) | 6 | 0.55 (0.22, 1.37) |
 | ≥58.5 | 9 | 1.03 (0.91, 1.17) | 13 | 1.40 (1.01, 1.95) | 3 | 1.62 (0.87, 3.03) | 4 | 1.62 (0.91, 2.88) | 2 | 1.65 (1.28, 2.13) | 7 | 0.91 (0.69, 1.2) | 6 | 0.80 (0.57, 1.13) |
Follow time(month) b | <68.5 | 7 | 1.04 (0.89, 1.20) | 8 | 1.29 (0.80, 2.10) | 2 | 4.51 (0.96, 21.13) | 5 | 1.42 (0.96, 2.08) | 5 | 1.50 (0.83, 2.71) | 7 | 0.88 (0.66, 1.17) | 8 | 0.89 (0.62, 1.28) |
 | ≥68.5 | 6 | 1.37 (0.94, 2.01) | 15 | 1.45 (1.03, 2.05) | 2 | 1.28 (0.36, 4.50) | 2 | 1.27 (0.11,14.01) | - | - | 3 | 0.39 (0.25, 0.62) | 4 | 0.43 (0.29, 0.65) |