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Table 4 Multivariate analysis of independent prognostic factors for DSS and OS in patients with NEC of the breast

From: Invasive neuroendocrine carcinoma of the breast: a population-based study from the surveillance, epidemiology and end results (SEER) database

Group DSS   OS  
HR (95% CI) P HR (95% CI) P
Age (>60 years vs ≤60 years) 1.82 (0.86-3.85) NS 2.02 (1.17-3.52) 0.012
Size (>20 mm vs ≤20 mm) 1.82 (0.91-3.64) NS 1.44 (0.89-2.32) NS
LN (positive vs negative) 2.54 (1.59-4.06) <0.0001 2.05 (1.51-2.80) <0.0001
Grade (III vs I, II) 1.18 (0.80-1.74) NS 1.24 (0.95-1.62) NS
ER status (positive vs negative) 1.23 (0.82-1.84) NS 0.95 (0.69-1.32) NS
PR status (positive vs negative) 0.59(0.41-0.86) 0.006 0.82 (0.60-1.10) NS
Radiation (yes vs no) 0.79 (0.41-1.55) NS 0.76 (0.47-1.22) NS
Surgery (yes vs no) 0.39 (0.16-0.96) 0.041 0.57 (0.27-1.20) NS
  1. DSS, disease-specific survival; OS, overall survival; NEC; neuroendocrine carcinoma; HR, hazard ratio; CI, confidence interval; NS, not significant; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor.