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Table 4 Multivariate analysis of independent prognostic factors for DSS and OS in patients with NEC of the breast

From: Invasive neuroendocrine carcinoma of the breast: a population-based study from the surveillance, epidemiology and end results (SEER) database

Group

DSS

 

OS

 

HR (95% CI)

P

HR (95% CI)

P

Age (>60 years vs ≤60 years)

1.82 (0.86-3.85)

NS

2.02 (1.17-3.52)

0.012

Size (>20 mm vs ≤20 mm)

1.82 (0.91-3.64)

NS

1.44 (0.89-2.32)

NS

LN (positive vs negative)

2.54 (1.59-4.06)

<0.0001

2.05 (1.51-2.80)

<0.0001

Grade (III vs I, II)

1.18 (0.80-1.74)

NS

1.24 (0.95-1.62)

NS

ER status (positive vs negative)

1.23 (0.82-1.84)

NS

0.95 (0.69-1.32)

NS

PR status (positive vs negative)

0.59(0.41-0.86)

0.006

0.82 (0.60-1.10)

NS

Radiation (yes vs no)

0.79 (0.41-1.55)

NS

0.76 (0.47-1.22)

NS

Surgery (yes vs no)

0.39 (0.16-0.96)

0.041

0.57 (0.27-1.20)

NS

  1. DSS, disease-specific survival; OS, overall survival; NEC; neuroendocrine carcinoma; HR, hazard ratio; CI, confidence interval; NS, not significant; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor.