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Table 3 Univariate survival analysis (Kaplan-Meier) in selected subgroups of patients with NEC of the breast according to characteristics

From: Invasive neuroendocrine carcinoma of the breast: a population-based study from the surveillance, epidemiology and end results (SEER) database

Characteristics 5-year DSS 5-year OS
n Survival rate (95% CI) HR (95% CI) P Survival rate (95% CI) HR (95% CI) P
Sex     NS    NS
 Male 2 Not reached    Not reached   
 Female 133 66.2 (54.2-75.7) Not reached   54.1 (42.7-64.3) 0.39 (0.05-2.84)  
Age (year)     NS    NS
 ≤60 55 67.9 (43.0-83.8)    59.1 (37.6-75.4)   
 >60 80 63.7 (49.2-75.1) 1.56 (0.74-3.32)   49.5 (35.8-61.8) 1.58 (0.85-2.91)  
Race     0.031    NS
 White 114 68.9 (55.4-78.9)    55.4 (42.8-66.4)   
 Black 13 63.3 (28.6-84.6) 1.63 (0.56-4.70)   58.0 (26.1-80.2) 1.27 (0.50-3.25)  
 Other 8 Not reached 3.15 (1.08-9.19)   Not reached 2.39 (0.94-6.11)  
AJCC TNM stage     <0.0001    <0.0001
 I 32 84.3 (43.2-96.6)    74.4 (43.4-90.0)   
 II 49 82.6 (64.4-92.0) 2.14 (0.44-10.4)   73.9 (56.3-85.3) 1.15 (0.42-3.14)  
 III 16 58.2 (21.0-82.8) 5.75 (1.05-31.5)   42.2 (14.3-68.2) 3.26 (1.09-9.75)  
 IV 32 20.7 (5.70-42.1) 18.0 (4.14-78.6)   17.1 (4.72-35.9) 6.92 (2.78-17.2)  
LN     NS    NS
 Negative 52 84.2 (58.1-94.7)    72.8 (49.6-86.7)   
 Positive 38 72.1 (48.8-86.1) 2.93(0.87-9.81)   62.7 (41.8-77.9) 1.96 (0.82-4.68)  
Size (mm)     <0.0001    0.002
 ≤20 73 81.8 (65.1-90.9)    67.9 (52.1-79.5)   
 >20 48 53.4 (34.7-68.9) 4.82 (2.08-11.2)   44.4 (27.7-59.9) 2.70 (1.45-5.03)  
Grade     NS    NS
 I 15 77.8 (31.6-94.7)    70.0 (29.9-90.0)   
 II 29 74.2 (41.3-90.4) 1.12 (0.22-5.78)   59.6 (31.6-79.3) 1.18 (0.31-4.46)  
 III 58 68.0 (51.0-80.2) 2.09 (0.47-9.28)   54.3 (38.9-67.3) 2.39 (0.72-7.98)  
ER status     NS    0.01
 Negative 36 Not reached    Not reached   
 Positive 72 66.0 (49.7-78.1) 0.85 (0.58-1.26)   64.8 (48.7-77.0) 0.65 (0.47-0.90)  
PR status     NS    0.022
 Negative 58 60.8 (40.3-76.2)    45.6 (27.8-61.7)   
 Positive 48 71.8 (53.3-84.0) 0.78 (0.52-1.15)   71.8 (53.3-84.0) 0.66 (0.46-0.94)  
Radiation     NS    NS
 No 85 69.5 (54.1-80.6)    50.2 (35.4-63.2)   
 Yes 50 62.0 (41.8-76.9) 1.10 (0.55-2.21)   58.3 (39.0-73.4) 0.75 (0.42-1.36)  
Surgery     0.003    0.012
 No 28 40.6 (17.6-62.6)    34.6 (14.9-55.3)   
 Yes 107 73.2 (59.7-82.8) 0.34 (0.16-0.69)   58.9 (45.9-69.9) 0.45 (0.25-0.84)  
  1. Data from the Surveillance, Epidemiology and End Results Program, 2003 to 2009. NEC, neuroendocrine carcinoma; DSS, disease-specific survival; OS, overall survival; n, number of cases; HR, hazard ratio; NS, not significant; CI, confidence interval; TNM, tumor-lymph nodes-metastasis; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor.