Table 3 Univariate survival analysis (Kaplan-Meier) in selected subgroups of patients with NEC of the breast according to characteristics
Characteristics | 5-year DSS | 5-year OS | |||||
|---|---|---|---|---|---|---|---|
n | Survival rate (95% CI) | HR (95% CI) | P | Survival rate (95% CI) | HR (95% CI) | P | |
Sex | NS | NS | |||||
Male | 2 | Not reached | Not reached | ||||
Female | 133 | 66.2 (54.2-75.7) | Not reached | 54.1 (42.7-64.3) | 0.39 (0.05-2.84) | ||
Age (year) | NS | NS | |||||
≤60 | 55 | 67.9 (43.0-83.8) | 59.1 (37.6-75.4) | ||||
>60 | 80 | 63.7 (49.2-75.1) | 1.56 (0.74-3.32) | 49.5 (35.8-61.8) | 1.58 (0.85-2.91) | ||
Race | 0.031 | NS | |||||
White | 114 | 68.9 (55.4-78.9) | 55.4 (42.8-66.4) | ||||
Black | 13 | 63.3 (28.6-84.6) | 1.63 (0.56-4.70) | 58.0 (26.1-80.2) | 1.27 (0.50-3.25) | ||
Other | 8 | Not reached | 3.15 (1.08-9.19) | Not reached | 2.39 (0.94-6.11) | ||
AJCC TNM stage | <0.0001 | <0.0001 | |||||
I | 32 | 84.3 (43.2-96.6) | 74.4 (43.4-90.0) | ||||
II | 49 | 82.6 (64.4-92.0) | 2.14 (0.44-10.4) | 73.9 (56.3-85.3) | 1.15 (0.42-3.14) | ||
III | 16 | 58.2 (21.0-82.8) | 5.75 (1.05-31.5) | 42.2 (14.3-68.2) | 3.26 (1.09-9.75) | ||
IV | 32 | 20.7 (5.70-42.1) | 18.0 (4.14-78.6) | 17.1 (4.72-35.9) | 6.92 (2.78-17.2) | ||
LN | NS | NS | |||||
Negative | 52 | 84.2 (58.1-94.7) | 72.8 (49.6-86.7) | ||||
Positive | 38 | 72.1 (48.8-86.1) | 2.93(0.87-9.81) | 62.7 (41.8-77.9) | 1.96 (0.82-4.68) | ||
Size (mm) | <0.0001 | 0.002 | |||||
≤20 | 73 | 81.8 (65.1-90.9) | 67.9 (52.1-79.5) | ||||
>20 | 48 | 53.4 (34.7-68.9) | 4.82 (2.08-11.2) | 44.4 (27.7-59.9) | 2.70 (1.45-5.03) | ||
Grade | NS | NS | |||||
I | 15 | 77.8 (31.6-94.7) | 70.0 (29.9-90.0) | ||||
II | 29 | 74.2 (41.3-90.4) | 1.12 (0.22-5.78) | 59.6 (31.6-79.3) | 1.18 (0.31-4.46) | ||
III | 58 | 68.0 (51.0-80.2) | 2.09 (0.47-9.28) | 54.3 (38.9-67.3) | 2.39 (0.72-7.98) | ||
ER status | NS | 0.01 | |||||
Negative | 36 | Not reached | Not reached | ||||
Positive | 72 | 66.0 (49.7-78.1) | 0.85 (0.58-1.26) | 64.8 (48.7-77.0) | 0.65 (0.47-0.90) | ||
PR status | NS | 0.022 | |||||
Negative | 58 | 60.8 (40.3-76.2) | 45.6 (27.8-61.7) | ||||
Positive | 48 | 71.8 (53.3-84.0) | 0.78 (0.52-1.15) | 71.8 (53.3-84.0) | 0.66 (0.46-0.94) | ||
Radiation | NS | NS | |||||
No | 85 | 69.5 (54.1-80.6) | 50.2 (35.4-63.2) | ||||
Yes | 50 | 62.0 (41.8-76.9) | 1.10 (0.55-2.21) | 58.3 (39.0-73.4) | 0.75 (0.42-1.36) | ||
Surgery | 0.003 | 0.012 | |||||
No | 28 | 40.6 (17.6-62.6) | 34.6 (14.9-55.3) | ||||
Yes | 107 | 73.2 (59.7-82.8) | 0.34 (0.16-0.69) | 58.9 (45.9-69.9) | 0.45 (0.25-0.84) | ||