Figure 5

Increased cell death and decreased cell proliferation on treatment with the allosteric Akt kinase inhibitor: TUNEL and Ki67 IHC was performed on control and treated samples A) Increased cell death on treatment with the inhibitor. B) Relative quantification was performed followed by statistical analysis to quantify the increase in death. There was a significant increase in cell death in treated animals. C) Shows a loss in cell proliferation on treatment with MK-2206. D) Bar graphs representing a highly significant loss in Ki67 staining in treated animals.