Figure 2

Maspin influence on survival and proliferative status of cells from breast tumor specimens. a, b - Kaplan-Meier analysis of survival of patients with breast cancer according to the localization and expression level of maspin; nuclear localization and higher level of this maspin pool positively affect the survival of patients unlike the cytoplasmically localized maspin and its higher level; c, d - correlation between proliferative status and maspin localization and expression level in breast cancer patients; strong and moderate level of nuclear maspin correlates with smaller subpopulation of cells expressing Ki-67 (less than 20%) in specimens from patients in contrast to weak expression or lack of nuclear maspin; there is no significant correlation between cytoplasmic maspin and Ki-67 expression; N = 166.