Table 1 Maltonis mean IC50 values in a panel of human derived sarcoma and human normal mesenchymal cells
Histotypea | Cell lineb | IC50 μM (± SE)c,f | Genetic alterationd | Doubling time (hours)e,f |
|---|---|---|---|---|
RHABDOMYOSARCOMA | RD/18 | 6.8 (± 2.1) | Altered 11p15.5 chromosome | 22 ± 0.1 |
SJ-RH4 | 5.6 (± 1.3) | (2;13)(q35;q14) PAX3 FKHR | 25 ± 1.2 | |
SJ-RH30 | 9.9 (± 2.7) | (2;13)(q35;q14) PAX3 FKHR | 26 ± 1.0 | |
OSTEOSARCOMA | IOR/OS10 | 5.5 (± 1.3) | Complex Karyotype | 30.4 ± 2.6 |
IOR/OS9 | 8.6 (± 1.8) | Complex Karyotype | 44.5 ± 2.4 | |
Saos-2 | 11.9 (± 3.1) | Complex Karyotype | 36.1 ± 4.4 | |
Saos-2/DX580 | 39.3 (± 2.6) | Complex Karyotype | 75.6 ± 5.7 | |
Saos-2/CDDP6ug | 43.3 (± 6.8) | Complex Karyotype | 44.3 ± 4.1 | |
U-2OS | 12.5 (± 0.7) | Complex Karyotype | 18.3 ± 0.2 | |
U-2OS/DX580 | 16.5 (± 0.4) | Complex Karyotype | 45.3 ± 4.7 | |
U-2OS/CDDP4ug | 56.1 (± 1.4) | Complex Karyotype | 38.6 ± 4.1 | |
EWING SARCOMA | 6647 | 3.1 (± 1.4) | t(11;22)(q24;q12) EWSR1-FLI1 TYPE II | 29 ± 2.3 |
LAP-35 | 11.6 (± 0.7) | t(11;22)(q24;q12) EWSR1-FLI1 TYPE II | 48.6 ± 4.2 | |
SK-N-MC | 3.9 (± 0.5) | t(11;22)(q24;q12) EWSR1-FLI1 TYPE I | 26.9 ± 0.5 | |
TC-71 | 2.6 (± 1.4) | t(11;22)(q24;q12) EWSR1-FLI1 TYPE I | 14.9 ± 1.4 | |
TC/DOXO8 | 5.0 (± 0.1) | t(11;22)(q24;q12) EWSR1-FLI1 TYPE I | 22.6 ± 2.8 | |
h-MSC | MES1 | >50 | n.d. | n.d. |
MES2 | >50 | n.d. | n.d. | |
DP-15 | >50 | n.d. | n.d. |