Primary tumor regression speed after radiotherapy and its prognostic significance in nasopharyngeal carcinoma: a retrospective study

Table 1 Multivariate analyses of prognostic factors in 188 NPC patients

Endpoint	Variable	Estimate	HR^†	95% CI*	P value^‡
OS	Regression speed	0.778	2.177	1.480-3.203	< 0.001
FFS	Regression speed	0.764	2.148	1.384-3.333	0.001
DMFS	Regression speed	0.812	2.252	1.296-3.912	0.004
LRFS	Regression speed	0.681	1.975	0.976-3.995	0.058

^†HR, Hazard ratio from Cox proportional hazards model; *CI, confidence interval; ^‡ P-values were calculated using an adjusted Cox proportional hazards model. OS, Overall survival; FFS, Failure-free survival; DMFS, Distant metastasis-free survival; LRFS, Local relapse-free survival. The following parameters were included in the model as covariates for each analysis: age (≤ 50 vs. > 50 years), sex, chemotherapy (yes vs. no), radiation technique (2-DRT vs. 3-DCRT), boosting (yes vs. no), T stage (T1-2 vs. T3-4), N stage (N0-1 vs. N2-3), primary tumor volume (< 19 cm³ vs. ≥ 19 cm³) and primary tumor regression speed at the end of RT (CRPT vs. PRPT vs. SDPT). Table contains only the results for primary tumor regression speed and other statistically significant variables.

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