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Table 2 The risk of association of smoking exposures during pregnancy with RAS status, NQO1 and MLL rearrangements, EAL cases, in a case-case analysis Brazil, 2000-2010

From: RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

  RAS wt n (%) RAS mut n (%) OR (95% CI) NQO1 wtn (%) NOQ1609CT an (%) OR (95% CI) MLL wt n (%) MLL r n (%) OR (95% CI)
Mother ever smoked          
No 55 (65.5) 24 (60.0) 1b 39 (57.4) 40 (71.4) 1b 45 (76.3) 30 (52.6) 1b
Yes 29 (34.5) 16 (40.0) 1.26 (0.58-2.75) 29 (42.6) 16 (28.6) 0.54 (0.25-1.14) 14 (23.7) 27 (47.4) 2.89 (1.31-6.40)
Mother smoked 3 months before pregnancy          
No 59 (70.2) 28 (70.0) 1b 44 (64.7) 43 (76.8) 1b 48 (81.4) 34 (59.6) 1b
Yes 25 (29.8) 12 (30.0) 1.01 (0.44-2.30) 24 (35.3) 13 (23.2) 0.55 (0.25-1.23) 11 (18.6) 23 (40.4) 2.95 (1.27-6.85)
Mother smoked during pregnancy          
No 67 (79.8) 31 (77.5) 1b 52 (76.5) 46 (82.1) 1b 52 (88.1) 41 (71.9) 1b
Yes 17 (20.2) 9 (22.5) 1.14 (0.46-2.85) 16 (23.5) 10 (17.9) 0.71 (0.29-1.71) 7 (11.9) 16 (28.1) 2.90 (1.09-7.71)
Someone in the house ever smoked c          
No 46 (59.0) 16 (42.1) 1b 38 (62.3) 24 (43.6) 1b 30 (53.6) 29 (53.7) 1b
Yes 32 (41.0) 22 (57.9) 1.98 (0.90-4.34) 23 (37.7) 31 (56.4) 2.13 (1.02-4.49) 23 (46.4) 25 (46.3) 1.00 (0.47-2.11)
  1. a NQ01 genotype status included allele variants CT and TT. b1 as a reference. cMothers reported the presence of someone smoking at home during the index pregnancy (second-hand smoking). MLL wt: Wild type MLL; MLL r: Rearranged MLL; n: number of cases; wt: wild type.