Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

BMC Cancer

Table 1 Clinical and tumor-related characteristics of the study population (N = 244)

Characteristics		No. of patients	%¹
Patient characteristics
Age (Years), mean±SD (range)	58,2±13,3 (29-91)
Weight (Kg), median (interquartile range)	67 (60-76)
Height (cm), median (interquartile range)	160 (154-163)
BMI (Kg/m ² ), median (interquartile range)	26,7 (23,5-30,44)
Menopausal status (yes)		126	65,6
Gestation (yes)		182	90,54
Breast-feeding (yes)		146	79,3
Oral contraception/HT (yes)		96	55,6
Family history of BC♯ (yes)		56	27,5
TC (mg/dL), median (interquartile range)	209,5 (191-231)
HDL-C (mg/dL), median (interquartile range)	53 (46-60)
LDL-C (mg/dL), median (interquartile range)	128 (110-153)
Triglycerides (mg/dL), median (interquartile range)	94 (74,5-126)
Tumor characteristics ²
Histological type	IDC	244	100
Tumor size (mm), median (interquartile range)	21 (14-30)
Tumor stage (T)	T1, ≤ 2 cm	122	50
	T2, 2-5 cm	115	47,2
	T3, >5 cm	7	2,8
Tumor differentiation grade	G1	27	12,4
	G2	134	61,5
	G3	57	26,2
Immunohistochemical subtypes	ER/PR positive	204	83,9
	Triple negative	23	9,5
	HER 2 Type	16	6,6
LVI positive		61	29,2
Nodal stage (N)	N0	137	56,9
	N1, 1-3 LN+	72	29,9
	N2, 4-9 LN+	18	7,47
	N3, ≥10 LN+	14	5,8
Clinical stage	I	84	34,4
	II	125	51,3
	III	35	14,3
Bilaterality (yes)		10	4,1

¹Frequency of known cases.
²Tumor characteristics based on The American Joint Committee on Cancer [58].
Histological type of breast cancer (IDC is presently named invasive carcinoma, NOS); Tumor Stage T of TNM Classification (T1≤2cm; T2:2-5cm; T3>5 cm); Tumor Differentiation Grade of Nothingham Histologic Score (G1, G2, G3); Immunohistochemical subtypes [Luminal A and B (ER/PR positive); Triple negative (ER/PR negative and Her2-neu negative); HER2 Type (ER/PR negative and Her2-neu positive)]; Pathological axillar Nodal Stage of TNM Classification (N0: no metastatic LN; N1: 1-3 metastatic LN; N2:4-9 metastatic lymph nodes; N3≥10 metastatic lymph nodes); Clinical Stage or Prognostic Stages Groups of American Joint Committee on Cancer (I, II, III,IV).
HT: Hormonal Therapy; BC: Breast Cancer; BMI: Body Mass Index; HT: Hormonal Therapy; TC: Total Cholesterol; LDL-C: Low Density Lipoprotein; HDL-C: High Density Lipoprotein IDC: Invasive Ductal Carcinoma; ER: Estrogen Receptor; PR: Progesterone Receptor; LVI: Lymphovascular Invasion; LN: Lymph Nodes.

ISSN: 1471-2407