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Table 1 ROC analysis (sensitivity, specificity, and the AUC) comparing ten selected FISH probe parameters

From: Identification of FISH biomarkers to detect chromosome abnormalities associated with prostate adenocarcinoma in tumour and field effect environment

FISH probe parameters

Tumour - BPH

Histologically benign - BPH

Sensitivity

Specificity

AUC

Sensitivity

Specificity

AUC

CEP8%Gain

79.40%

76.90%

0.853

82.40%

76.90%

0.871

MYC%Gain

91.20%

76.90%

0.908

82.40%

76.90%

0.846

CEP7%Abnormal

88.20%

80.80%

0.896

76.50%

80.80%

0.845

PTEN%Loss

58.80%

80.80%

0.726

70.60%

80.80%

0.827

PTEN/CEP10%Loss

82.40%

80.80%

0.881

64.70%

80.80%

0.788

CEP10%Gain

94.10%

84.60%

0.93

76.50%

84.60%

0.786

CEP10%Abnormal

79.40%

80.80%

0.865

76.50%

73.10%

0.775

CEP7%Gain

85.30%

84.60%

0.886

70.60%

76.90%

0.77

CEP8%Abnormal

94.10%

88.50%

0.966

64.70%

76.90%

0.752

LPL%Abnormal

79.40%

92.30%

0.945

64.70%

76.90%

0.736

  1. The analyses of tumour ROI vs. BPH, and benign ROI vs. BPH performed independently. Sensitivity and specificity calculated at the optimal cut-off in each of the two analyses for each parameter.