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Table 1 ROC analysis (sensitivity, specificity, and the AUC) comparing ten selected FISH probe parameters

From: Identification of FISH biomarkers to detect chromosome abnormalities associated with prostate adenocarcinoma in tumour and field effect environment

FISH probe parameters Tumour - BPH Histologically benign - BPH
Sensitivity Specificity AUC Sensitivity Specificity AUC
CEP8%Gain 79.40% 76.90% 0.853 82.40% 76.90% 0.871
MYC%Gain 91.20% 76.90% 0.908 82.40% 76.90% 0.846
CEP7%Abnormal 88.20% 80.80% 0.896 76.50% 80.80% 0.845
PTEN%Loss 58.80% 80.80% 0.726 70.60% 80.80% 0.827
PTEN/CEP10%Loss 82.40% 80.80% 0.881 64.70% 80.80% 0.788
CEP10%Gain 94.10% 84.60% 0.93 76.50% 84.60% 0.786
CEP10%Abnormal 79.40% 80.80% 0.865 76.50% 73.10% 0.775
CEP7%Gain 85.30% 84.60% 0.886 70.60% 76.90% 0.77
CEP8%Abnormal 94.10% 88.50% 0.966 64.70% 76.90% 0.752
LPL%Abnormal 79.40% 92.30% 0.945 64.70% 76.90% 0.736
  1. The analyses of tumour ROI vs. BPH, and benign ROI vs. BPH performed independently. Sensitivity and specificity calculated at the optimal cut-off in each of the two analyses for each parameter.