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Table 1 The risk associations between ARID5B rs10821936 genotype and MLL translocation partner genes or MLL breakpoint region, Brazil, 2003-2013

From: ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

  Controls MLLtranslocation partner genes MLLbreakpoint regiona
    MLL-AFF1(n = 44)   MLL-MLLT1(n = 21)   MLL-MLLT3(n = 17)   A (n = 15) and B (n = 8)   C (n = 18)
  n n OR (95% CI)b,c n OR (95% CI)b,c n OR (95% CI)b,c n OR (95% CI)b,c n OR (95% CI)b,c
ARID5B            
   rs10821936            
   TT 200 11 1.00 6 1.00 2 1.00 2 1.00 5 1.00
   TC 205 27 3.26 (1.42-7.49) 11 2.82 (0.89-8.93) 12 8.62 (1.77-41.94) 17 12.76 (2.66-61.23) 12 3.45 (1.08-11.05)
   CC 68 6 1.95 (0.62-6.11) 4 2.12 (0.52-8.63) 3 5.18 (0.79-34.02) 4 6.65 (1.08-41.15) 1 0.85 (0.09-8.25)
   TC + CC 273 33 2.79 (1.27-6.11) 15 2.53 (0.89-7.22) 15 7.10 (1.54-32.68) 22 10.25 (2.24-46.81) 14 2.72 (0.88-8.43)
  1. n, number of individuals; OR, odds ratio; CI, confidence intervals; aThe MLL breakpoint region was subdivided according to Meyer et al., 201332 as follows: (A) Exon 9-Intron 9, (B) Exon 10-Intron 10, (C) Intron 11; bAdjusted on age; cAdjusted on skin color.