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Table 3 Survival rates according to genomic regions

From: Impact of chromosomal instability on colorectal cancer progression and outcome

Genomic regions S2S3PT (n=72) RFS OS
No. of relapse HR 95% CI 3-year RFS rate (%) No. of death HR 95% CI 5-year OS rate (%)
chr16p13.3 Normal 49 (68.1%) 13 1   72.8 11 1   71.8
chr16:0-2,410,722 Gain 16 (22.2%) 5 1.21 [0.43;3.41] 73.7 4 1.05 [0.33;3.31] 62.7
167 genes Loss 7 (9.7%) 4 10.9 [3.10;38.6] 0 4 5.33 [1.63;17.5] 22.2
     p*=0.007   p**< 0.001   p*=0.05   p**=0.007
chr19q13.32-q13.33 Normal 47 (66.2%) 17 1   66.8 12 1   66.7
chr19:52,114,272-56,657,958 Gain 16 (22.5%) 1 0.17 [0.02;1.30] 91.7 3 0.77 [0.22;2.75] 80.4
285 genes Loss 8 (11.3%) 4 5.04 [1.55;16.4] 26.3 4 4.36 [1.33;14.2] 23.8
  Missing 1         
     p*=0.003   p**<0.001   p*=0.07   p**=0.016
  1. Abbreviations: RFS relapse-free survival, OS overall survival, HR hazard ratio, CI confidence interval, *, Likelihood ratio test; **, log-rank test.