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Table 1 Baseline characteristics of the studies in the meta-analysis

From: Prognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: a meta-analysis

Study (Reference) Year Country Treatment Sample size(Male, n) Mean/median Ages(years) Tumor vascular invasion (yes) NLR (cut-off used;n)
Halazun[38] 2009 USA LT 150(119) 57.1 45 5
Motomura[30] 2013 Japan LT 158(92) 57 59 4
Bertuzzo[36] 2011 Italy LT 219(186) 57 124 5
Limaye[27] 2013 USA LT 160(130) 55.5/55.1 25 5
Wang[34] 2011 China LT 101(92) 48.4 30 3
Gomez[39] 2008 UK SR 96(72) 65 49 5
Mano[24] 2013 Japan SR 958(689) 67 NA 2.81
McNally[29] 2013 USA TACE 103(77) 56 NA 5
Huang[37] 2011 China TACE 145(134) 49 39 3.3
Pinato1[33] 2012 UK TACE 54(40) 63 NA 5
Chen[35] 2011 Taiwan RF 192(95) 65.7 NA 2.4
Dan[25] 2013 China RF 178(159) 57 NA 1.9
Oh[26] 2013 Korea Mix 318((240) 58 107 2.3
Pinato2[32] 2012 UK Mix 112(90) 65 NA 5
Kinoshita[31] 2012 Japan Mix 150(106) 72 NA 5
Study Sampling time Follow-up Mean/median (months) Outcome measured Multivariate analysis Patients with elevated NLR Study quality (Points)
Halazun[38] Pre-LT 37.2 DFS/ OS yes 13 8/9
Motomura[30] Pre-LT 40.3 DFS/OS yes 26 8/9
Bertuzzo[36] Pre-LT 40 DFS/ OS yes 23 5/9
Limaye[27] Pre-LT 38 DFS/ OS yes 28 8/9
Wang[34] Pre-LT 34.2 DFS/ OS yes 33 7/9
Gomez[39] Pre-SR 30 DFS/ OS yes 26 6/9
Mano[24] Pre-SR NA DFS/ OS yes 238 5/9
McNally[29] Pre-TACE 11.1 OS no 18 7/9
Huang[37] Pre- TACE 10 OS yes 59 8/9
Pinato1[33] Pre-TACE NA OS Yes 9 5/9
Chen[35] Pre-RFA 34 OS/DFS yes 81 7/9
Dan[25] Pre-RFA 52.7 OS/DFS yes 91 7/9
Oh[26] Pre-treatment 13.9 OS yes 189 7/9
Pinato2[32] Pre-treatment 10 OS yes 25 7/9
Kinoshita[31] Pre-treatment 18 0S no 15 6/9
  1. M, male; F, female; NA, not available.
  2. Treatment describes whether the patients received surgical resection (SR), or liver transplantation (LT) of HCC, transarterial chemoembolization (TACE), radiofrequency ablation(RFA), mixed treatment (Mix) including locoregional ,systemic treatments or supportive care.
  3. Tumor vascular invasion was defined as presence of either macro- or microscopic vascular invasion (including portal vein invasion, etc.).
  4. OS, overall survival; DFS, disease-free survival.
  5. Study quality is listed using the results of the Newcastle –Ottawa questionnaire.