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Table 1 Clinical variables examined

From: The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management

Clinical variables LDH LDH LDH LDH Total
≤407 U/l >407 U/l Decreased Increased
Patients 53 (%) 25 (%) 26 52 78
Gender Male 52 (98) 21 (84) 24 (92) 49 (94) 73
Female 1 (2) 4 (16) 2 (8) 3 (6) 5
Median age < 69 28 (53) 11 (44) 12 (46) 27 (52) 39
≥ 69 25 (47) 14 (56) 14 (54) 25 (48) 39
ECOG 0 36 (68) 16 (64) 15 (58) 37 (71) 52
1-2 17 (32) 9 (36) 11 (42) 15 (29) 26
BCLC B 14 (26) 10 (40) 8 (32) 16 (31) 24
C 39 (74) 15 (60) 18 (68) 36 (69) 54
Median serum α-FP level ≥ 19 ng/mL 13 (25) 7 (28) 5 (19) 15 (29) 20
< 19 ng/mL 40 (75) 18 (72) 21 (81) 37 (71) 58
Comorbidities (>5%) Cardiovascular 11 (21) 4 (16) 5 (19) 10 (19) 15
Diabetes 6 (11) 2 (8) 3 (12) 5 (10) 8
Other previous neoplasm 3 (6) 0 (0) 1 (4) 2 (4) 3
Etiology HCV 20 (38) 9 (36) 10 (38) 19 (37) 29
HBV 13 (24) 7 (28) 5 (19) 15 (29) 20
HBV-HCV 2 (4) 0 (0) 1 (4) 1 (2) 2
Alcoholic 9 (17) 5 (20) 7 (27) 7 (13) 14
Alcoholic - HBV-HCV 0 (0) 1 (4) 0 (0) 1 (2) 1
Methabolic-Cryptogenetic 9 (17) 3 (12) 3 (12) 9 (17) 12
Prior locoregional treatments Yes 25 (47) 13 (52) 15 (58) 23 (44) 38
No 28 (53) 12 (48) 11 (42) 29 (56) 40
Prior surgery Yes 11 (21) 4 (16) 6 (23) 9 (17) 15
No 42 (79) 21 (84) 20 (77) 43 (83) 63
AST < UNR (40 U/L) 19 (36) 9 (36) 14 (54) 14 (27) 28
≥ UNR (40 U/L) 34 (64) 16 (64) 12 (46) 38 (73) 50
ALT < UNR (40 U/L) 23 (43) 11 (44) 9 (35) 25 (48) 34
≥ UNR (40 U/L) 30 (57) 14 (56) 17 (65) 27 (52) 44
CRP < UNR (0.5 mg/dL) 11 (21) 4 (16) 6 (23) 9 (17) 15
≥ UNR (0.5 mg/dL) 42 (79) 21 (84) 20 (77) 43 (83) 63
Viral load HCV RNA < 5.3 log10 IU/mL 7 (35) 5 (56) 3 (30) 9 (47) 12
≥ 5.3 log10 IU/mL 13 (65) 4 (44) 7 (70) 10 (53) 17
Viral load HBC DNA < 2000 IU/mL 6 (46) 3 (43) 3 (60) 6 (40) 9
≥ 2000 IU/ml 7 (54) 4 (57) 2 (40) 9 (60) 11
  1. ECOG PS (Eastern Cooperative Oncology Group performance status), BCLC (Barcelona Clinic Liver Cancer), AST (aspartate aminotransferase), ALT (alanine aminotransferase), CRP (C reactive protein), UNR (upper normal rate).