Table 1 Clinical variables examined
Clinical variables | LDH | LDH | LDH | LDH | Total | |
|---|---|---|---|---|---|---|
≤407 U/l | >407 U/l | Decreased | Increased | |||
Patients | 53 (%) | 25 (%) | 26 | 52 | 78 | |
Gender | Male | 52 (98) | 21 (84) | 24 (92) | 49 (94) | 73 |
Female | 1 (2) | 4 (16) | 2 (8) | 3 (6) | 5 | |
Median age | < 69 | 28 (53) | 11 (44) | 12 (46) | 27 (52) | 39 |
≥ 69 | 25 (47) | 14 (56) | 14 (54) | 25 (48) | 39 | |
ECOG | 0 | 36 (68) | 16 (64) | 15 (58) | 37 (71) | 52 |
1-2 | 17 (32) | 9 (36) | 11 (42) | 15 (29) | 26 | |
BCLC | B | 14 (26) | 10 (40) | 8 (32) | 16 (31) | 24 |
C | 39 (74) | 15 (60) | 18 (68) | 36 (69) | 54 | |
Median serum α-FP level | ≥ 19 ng/mL | 13 (25) | 7 (28) | 5 (19) | 15 (29) | 20 |
< 19 ng/mL | 40 (75) | 18 (72) | 21 (81) | 37 (71) | 58 | |
Comorbidities (>5%) | Cardiovascular | 11 (21) | 4 (16) | 5 (19) | 10 (19) | 15 |
Diabetes | 6 (11) | 2 (8) | 3 (12) | 5 (10) | 8 | |
Other previous neoplasm | 3 (6) | 0 (0) | 1 (4) | 2 (4) | 3 | |
Etiology | HCV | 20 (38) | 9 (36) | 10 (38) | 19 (37) | 29 |
HBV | 13 (24) | 7 (28) | 5 (19) | 15 (29) | 20 | |
HBV-HCV | 2 (4) | 0 (0) | 1 (4) | 1 (2) | 2 | |
Alcoholic | 9 (17) | 5 (20) | 7 (27) | 7 (13) | 14 | |
Alcoholic - HBV-HCV | 0 (0) | 1 (4) | 0 (0) | 1 (2) | 1 | |
Methabolic-Cryptogenetic | 9 (17) | 3 (12) | 3 (12) | 9 (17) | 12 | |
Prior locoregional treatments | Yes | 25 (47) | 13 (52) | 15 (58) | 23 (44) | 38 |
No | 28 (53) | 12 (48) | 11 (42) | 29 (56) | 40 | |
Prior surgery | Yes | 11 (21) | 4 (16) | 6 (23) | 9 (17) | 15 |
No | 42 (79) | 21 (84) | 20 (77) | 43 (83) | 63 | |
AST | < UNR (40 U/L) | 19 (36) | 9 (36) | 14 (54) | 14 (27) | 28 |
≥ UNR (40 U/L) | 34 (64) | 16 (64) | 12 (46) | 38 (73) | 50 | |
ALT | < UNR (40 U/L) | 23 (43) | 11 (44) | 9 (35) | 25 (48) | 34 |
≥ UNR (40 U/L) | 30 (57) | 14 (56) | 17 (65) | 27 (52) | 44 | |
CRP | < UNR (0.5 mg/dL) | 11 (21) | 4 (16) | 6 (23) | 9 (17) | 15 |
≥ UNR (0.5 mg/dL) | 42 (79) | 21 (84) | 20 (77) | 43 (83) | 63 | |
Viral load HCV RNA | < 5.3 log10 IU/mL | 7 (35) | 5 (56) | 3 (30) | 9 (47) | 12 |
≥ 5.3 log10 IU/mL | 13 (65) | 4 (44) | 7 (70) | 10 (53) | 17 | |
Viral load HBC DNA | < 2000 IU/mL | 6 (46) | 3 (43) | 3 (60) | 6 (40) | 9 |
≥ 2000 IU/ml | 7 (54) | 4 (57) | 2 (40) | 9 (60) | 11 | |