Variable | Definition | Down-regulated (n=13) | Up-regulated (n=35) | P |
---|---|---|---|---|
Age | ≥65 years / <65 years | 7 / 6 | 16 / 19 | 0.620 |
Sex | female / male | 3 / 10 | 2 / 33 | 0.100 |
Virus | HCV / HBV / none | 11 / 2 / 0 | 27 / 5 / 3 | 0.374 |
Child classification | B / A | 2 / 11 | 3 / 32 | 0.507 |
Liver damage score | B / A | 9 / 4 | 10 / 25 | 0.011 |
Tumor size | ≥50 mm / <50 mm | 3 / 10 | 10 / 25 | 0.700 |
Tumor number | multiple / solitary | 4 / 9 | 13 / 22 | 0.685 |
Differentiation | poor / mod / well | 0 / 12 / 1 | 1 / 30 / 4 | 0.699 |
Growth type | invasive / expansive | 1 / 12 | 4 / 29 | 0.654 |
Capsule formation | present / absent | 13 / 0 | 27 / 7 | 0.026 |
Septum formation | present / absent | 10 / 2 | 26 / 7 | 0.732 |
Serosal invasion | present / absent | 0 / 7 | 4 / 16 | 0.105 |
Vessel invasion | present / absent | 1 / 12 | 9 / 26 | 0.176 |
Cirrhosis | present / absent | 9 / 4 | 14 / 21 | 0.077 |
AFP | ≥20 ng/ml / <20 ng/ml | 10 / 3 | 18 / 17 | 0.115 |
Japanese stage | III + IV / I + II | 4 / 9 | 12 / 23 | 0.820 |
TNM stage | III + IV / I + II | 2 / 11 | 8 / 27 | 0.562 |
Methylation in tumor | present / absent | 10 / 3 | 10 / 25 | 0.002 |