Skip to main content

Table 3 Correlation between COL1A1 mRNA expression and clinicopathological features

From: Identification of the collagen type 1 alpha 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma

Variable Definition Down-regulated (n=13) Up-regulated (n=35) P
Age ≥65 years / <65 years 7 / 6 16 / 19 0.620
Sex female / male 3 / 10 2 / 33 0.100
Virus HCV / HBV / none 11 / 2 / 0 27 / 5 / 3 0.374
Child classification B / A 2 / 11 3 / 32 0.507
Liver damage score B / A 9 / 4 10 / 25 0.011
Tumor size ≥50 mm / <50 mm 3 / 10 10 / 25 0.700
Tumor number multiple / solitary 4 / 9 13 / 22 0.685
Differentiation poor / mod / well 0 / 12 / 1 1 / 30 / 4 0.699
Growth type invasive / expansive 1 / 12 4 / 29 0.654
Capsule formation present / absent 13 / 0 27 / 7 0.026
Septum formation present / absent 10 / 2 26 / 7 0.732
Serosal invasion present / absent 0 / 7 4 / 16 0.105
Vessel invasion present / absent 1 / 12 9 / 26 0.176
Cirrhosis present / absent 9 / 4 14 / 21 0.077
AFP ≥20 ng/ml / <20 ng/ml 10 / 3 18 / 17 0.115
Japanese stage III + IV / I + II 4 / 9 12 / 23 0.820
TNM stage III + IV / I + II 2 / 11 8 / 27 0.562
Methylation in tumor present / absent 10 / 3 10 / 25 0.002
  1. HCV, hepatitis type C virus; HBV, hepatitis type B virus; AFP, alpha-fetoprotein.