Figure 4
![Figure 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2407-14-108/MediaObjects/12885_2013_Article_5208_Fig4_HTML.jpg)
Promoter methylation status in 48 tumor tissues and matched noncancerous liver tissues. a A total of 20 tumor tissues and 11 noncancerous tissues showed promoter methylation. b MSP and UMSP results of two representative cases. c The 48 cases were divided into13 COL1A1 expression down-regulated cases and 35 up-regulated cases in tumor tissues. Promoter methylated cases were indicated by red lines. Promoter methylation and the mRNA expression pattern were significantly correlated (P = 0.002).