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Table 3 Risk for esophageal cancer for continuous z-scores of single metabolic factors and the metabolic syndrome

From: Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project

Exposure Adenocarcinoma (n = 114) Squamous cell carcinoma (n = 184)
  RR model 1 1 RR model 2 2 Regression calibrated RR 3 RR model 1 1 RR model 2 2 Regression calibrated RR 3
BMI 1.57 (1.35–1.83) 1.58 (1.34–1.87) 1.64 (1.30–2.07) 0.69 (0.58–0.81) 0.60 (0.50–0.72) 0.50 (0.40–0.63)
Mid blood pressure 1.10 (0.92–1.32) 0.99 (0.81–1.21) 0.95 (0.66–1.39) 1.28 (1.13–1.46) 1.40 (1.23–1.60) 1.77 (1.37–2.29)
Glucose 1.04 (0.86–1.24) 0.97 (0.80–1.17) 0.99 (0.49–1.99) 1.11 (0.98–1.27) 1.11 (0.97–1.27) 1.40 (0.85–2.31)
Cholesterol 1.02 (0.84–1.23) 0.95 (0.77–1.17) 0.92 (0.66–1.29) 1.07 (0.92–1.24) 1.08 (0.92–1.26) 1.10 (0.85–1.41)
Triglycerides 1.20 (0.99–1.45) 1.05 (0.85–1.30) 1.13 (0.71–1.80) 0.99 (0.86–1.16) 1.05 (0.88–1.24) 1.03 (0.71–1.49)
MetS4 1.36 (1.13–1.64) 1.56 (1.19–2.05) 1.06 (0.91–1.24) 1.09 (0.87–1.36)
  1. Relative risk with 95% confidence interval for esophageal adenocarcinoma and squamous cell carcinoma for continuous z-score of single metabolic factors and the combined z-score for the metabolic syndrome.
  2. 1Relative risk from Cox regression models, with attained age as time scale, stratified by cohort and categories of birth year. Adjusted for sex, age at baseline and smoking.
  3. 2As model 1 but in addition adjusted for the z-score of analyzed factors i.e. BMI, mid BP, glucose, cholesterol and triglycerides.
  4. 3As model 2 and corrected by regression calibration, see text.
  5. 4Z score for MetS is adjusted for sex, age at baseline and smoking status. Corrected for regression dilution bias, see text.
  6. Abbreviations: MetS metabolic syndrome, BMI body mass index, RR relative risk.