Spheroids from mouse pancreatic cancer. [A] PDAC cells from a mouse bearing mutated Kras and Trp53 in the pancreas (KPC cells) are compared to the human PDAC Panc-1 cell line in their ability to form spheroids when grown under 3D culture conditions. [B] Drug assay performed on KPC cells. Different compounds are used at the indicated concentrations and cell viability of 2D versus 3D culture is compared. Data are plotted as percentage of the respective untreated control (CTR). A representative experiment out of three is shown.