Figure 3
From: Regional differences in prostaglandin E2 metabolism in human colorectal cancer liver metastases
Functional 15-PGDH protein levels are increased in the central area of CRCLM, but NAD+/NADH levels are decreased, relative to peripheral tumour tissue. A) Maximal ex vivo 15-PGDH activity in CRCLM tissue in the presence of excess substrate and co-factors, B) NAD+ levels and C) NADH levels in peripheral and central CRCLM tissue. In each case, a box and whisker plot demonstrates the median, inter-quartile range and range of values.