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Figure 5 | BMC Cancer

Figure 5

From: Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice

Figure 5

Effect of ABZ, 2ME, and their combination on inhibition of tumor cell proliferation, angiogenesis, and apoptosis in HCT-116 subcutaneous tumor. Ki67-positive cells (brown) were counted and reported as the percentage of the total number of cells in proliferative phases in each field. CD31-positive vessel area (brown) were measured per high-power field (103 pixels). Cells underwent apoptosis (brown) were counted and reported as the percentage of total cells. (1) Vehicle control, (2) 25 mg/kg ABZ, (3) 50 mg/kg ABZ, (4) 25 mg/kg 2ME, (5) 25 mg/kg ABZ plus 2ME, and (6) 50 mg/kg ABZ plus 2ME. (*Pā€‰<ā€‰0.05 and **Pā€‰<ā€‰0.001 compared with single agents).

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