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Table 5 Relationships between mutations and MSI patterns

From: Correlation of MLH1 and MGMTexpression and promoter methylation with genomic instability in patients with thyroid carcinoma

 Mutation status N (%) p
BRAF V600E*
      Positive 18/20 (90%) 1.000
     Negative 17/19 (89%)
RET/PTC*
      Positive 13/16 (81%) 0.642
     Negative 17/19 (89%)
Transitions (IDH1 + NRAS)
      Positive 9/11 (82%) 0.631
     Negative 22/25 (88%)
Point mutations (BRAF + IDH1 + NRAS)
      Positive 35/41 (85%) 1.000
     Negative 22/25 (88%)
  1. * Analysis performed only in the PTC group.
  2. Negative group comprises only samples without any of the alterations investigated.