Methylation status
|
Mutational status
|
N (%)
|
p
|
---|
BRAF V600E*
|
---|
MLH1
|
Methylated
|
Positive
|
4/20 (20%)
|
0.048
|
| |
Negative
|
10/19 (53%)
| |
|
Unmethylated
|
Positive
|
16/20 (80%)
| |
| |
Negative
|
9/19 (47%)
| |
MGMT
|
Methylated
|
Positive
|
14/20 (70%)
|
0.333
|
| |
Negative
|
10/19 (53%)
| |
|
Unmethylated
|
Positive
|
6/20 (30%)
| |
| |
Negative
|
9/19 (47%)
| |
RET/PTC*
|
MLH1
|
Methylated
|
Positive
|
8/16 (50%)
|
1.000
|
| |
Negative
|
10/19 (53%)
| |
|
Unmethylated
|
Positive
|
8/16 (50%)
| |
| |
Negative
|
9/19 (47%)
| |
MGMT
|
Methylated
|
Positive
|
9/16 (56%)
|
1.000
|
| |
Negative
|
10/19 (53%)
| |
|
Unmethylated
|
Positive
|
7/16 (44%)
| |
| |
Negative
|
9/19 (47%)
| |
Transitions (IDH1 + NRAS)
|
MLH1
|
Methylated
|
Positive
|
5/11 (45%)
|
1.000
|
| |
Negative
|
13/25 (52%)
| |
|
Unmethylated
|
Positive
|
6/11 (55%)
| |
| |
Negative
|
12/25 (48%)
| |
MGMT
|
Methylated
|
Positive
|
9/11 (82%)
|
0.268
|
| |
Negative
|
15/25 (60%)
| |
|
Unmethylated
|
Positive
|
2/11 (18%)
| |
| |
Negative
|
10/25 (40%)
| |
Point mutations (BRAF + IDH1 + NRAS)
|
MLH1
|
Methylated
|
Positive
|
14/41 (34%)
|
0.199
|
| |
Negative
|
13/25 (52%)
| |
|
Unmethylated
|
Positive
|
27/41 (66%)
| |
| |
Negative
|
12/25 (48%)
| |
MGMT
|
Methylated
|
Positive
|
29/41 (71%)
|
0.426
|
| |
Negative
|
15/25 (60%)
| |
|
Unmethylated
|
Positive
|
12/41 (29%)
| |
| |
Negative
|
10/25 (40%)
| |
- * Analysis performed only in the PTC group.
- Negative group comprises only samples without any of the alterations investigated.