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Table 2 Univariate and multivariate analysis of prognostic factors of overall survival by Cox regression model

From: Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma

  Univariate Multivariate
  HR (95% CI) Pvalue HR (95% CI) Pvalue
Sex (male) 0.842 (0.604–1.173) 0.309   
Age > 60 (years) 0.777 (0.586–1.031) 0.080   
Cause (viral) 0.978 (0.652–1.469) 0.916   
ALT > 40 (IU/L) 1.511 (1.146–1.992) 0.003 1.333 (0.985–1.804) 0.062
Child-Pugh class 1.803 (1.480–2.198) < 0.001 1.711 (1.377–2.125) < 0.001
Tumor size > 5 (cm) 3.548 (2.622–4.801) < 0.001 1.778 (1.209–2.615) 0.003
Tumor multiplicity (≥ 2) 2.023 (1.510–2.711) < 0.001 1.391 (1.023–1.892) 0.035
Presence of PVT 4.197 (3.141–5.609) < 0.001 1.827 (1.284–2.598) 0.001
Presence of metastasis 3.002 (2.178–4.139) < 0.001 1.242 (0.868–1.779) 0.236
AFP > 200 (ng/mL) 2.783 (2.099–3.690) < 0.001 1.734 (1.248–2.407) 0.001
CRP > 6.3 (mg/L) 3.923 (2.929–5.255) < 0.001 1.519 (1.049–2.199) 0.027
NLR > 2.3 3.050 (2.223–4.185) < 0.001 1.601 (1.124–2.280) 0.009
  1. HR, hazard ratio; CI, confidence interval; ALT, alanine aminotransferase; PVT, portal vein thrombosis; AFP, α-fetoprotein; CRP, C-reactive protein; NLR, neutrophil-to-lymphocyte ratio.