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Table 2 Univariate and multivariate analysis of prognostic factors of overall survival by Cox regression model

From: Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma

 

Univariate

Multivariate

 

HR (95% CI)

Pvalue

HR (95% CI)

Pvalue

Sex (male)

0.842 (0.604–1.173)

0.309

  

Age > 60 (years)

0.777 (0.586–1.031)

0.080

  

Cause (viral)

0.978 (0.652–1.469)

0.916

  

ALT > 40 (IU/L)

1.511 (1.146–1.992)

0.003

1.333 (0.985–1.804)

0.062

Child-Pugh class

1.803 (1.480–2.198)

< 0.001

1.711 (1.377–2.125)

< 0.001

Tumor size > 5 (cm)

3.548 (2.622–4.801)

< 0.001

1.778 (1.209–2.615)

0.003

Tumor multiplicity (≥ 2)

2.023 (1.510–2.711)

< 0.001

1.391 (1.023–1.892)

0.035

Presence of PVT

4.197 (3.141–5.609)

< 0.001

1.827 (1.284–2.598)

0.001

Presence of metastasis

3.002 (2.178–4.139)

< 0.001

1.242 (0.868–1.779)

0.236

AFP > 200 (ng/mL)

2.783 (2.099–3.690)

< 0.001

1.734 (1.248–2.407)

0.001

CRP > 6.3 (mg/L)

3.923 (2.929–5.255)

< 0.001

1.519 (1.049–2.199)

0.027

NLR > 2.3

3.050 (2.223–4.185)

< 0.001

1.601 (1.124–2.280)

0.009

  1. HR, hazard ratio; CI, confidence interval; ALT, alanine aminotransferase; PVT, portal vein thrombosis; AFP, α-fetoprotein; CRP, C-reactive protein; NLR, neutrophil-to-lymphocyte ratio.